Art

J-GLOBAL ID：201102263460274452   Reference number：11A1165102

Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro

Clostridium perfringens腸毒素の変異C末端フラグメントはクラウディン-4への親和性の増加を示し,in vitroでタイトジャンクションを可逆的に調節する

Author (6)： TAKAHASHI Azusa (Lab. of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka Univ., Osaka, JPN) ,  KONDOH Masuo (Lab. of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka Univ., Osaka, JPN) ,  UCHIDA Hiroshi (Asubio Pharma Co., Ltd., Kobe, JPN) ,  KAKAMU Yohei (Lab. of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka Univ., Osaka, JPN) ,  HAMAKUBO Takao (Dep. of Molecular Biology and Medicine, Res. Center for Advanced Sci. and Technol., The Univ. of Tokyo, Tokyo, JPN) ,  YAGI Kiyohito (Lab. of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka Univ., Osaka, JPN)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 410  Issue： 3  Page： 466-470  Publication year： Jul. 08, 2011 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Clostridium perfringens ,  *enterotoxin ,  *transmembrane protein ,  modulator ,  *cell junction ,  affinity ,  site-directed mutagenesis ,  plasma resonance ,  clostridium perfringens enterotoxin ,  *Claudin-4 ,  *Tight Junctions ,  binding affinity ,  microorganism ,  Spore-Forming Bacteria ,  Bacillaceae ,  *Cell Physiological Phenomena
Semi thesaurus term： Clostridium perfringens ,  modulator ,  SPR

JST classification (2)： Microorganism biochemistry  (EG03020N) ,  Function of cell components  (EF03060C)

Terms in the title (9)： Clostridium ,  腸毒素 ,  変異 ,  C末端 ,  フラグメント ,  クラウディン ,  親和性 ,  タイトジャンクション ,  調節