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J-GLOBAL ID：201102285373348974   Reference number：11A1769464

Association between Cancer Risk and Drug-metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Cases of Lung Cancer in Japan

日本の肺癌症例における癌リスクと薬物代謝酵素遺伝子(CYP2A6,CYP2A13,CYP4B1,SULT1A1,GSTM1およびGSTT1)多型の間の関連性

Author (11)： TAMAKI Yuichiro (Lab. of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  ARAI Tomio (Dep. of Pathology, Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology) ,  SUGIMURA Haruhiko (First Dep. of Pathology, Hamamatsu Univ. School of Medicine) ,  SASAKI Takamitsu (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  HONDA Masashi (Lab. of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  MUROI Yuka (Lab. of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  MATSUBARA Yoichi (Dep. of Medical Genetics, Tohoku Univ. School of Medicine) ,  KANNO Shuichi (Dep. of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical Univ.) ,  ISHIKAWA Masaaki (Dep. of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical Univ.) ,  HIRASAWA Noriyasu (Lab. of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  HIRATSUKA Masahiro (Lab. of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku Univ.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 26  Issue： 5  Page： 516-522 (J-STAGE)  Publication year： 2011 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： CYP2A13 ,...

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JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Carcinogenic mechanisms and factors  (GE02020C)

Reference (28)：

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• 5) Su, T., Bao, Z., Zhang, Q. Y., Smith, T. J., Hong, J. Y. and Ding, X.: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 60: 5074–5079 (2000).

Terms in the title (13)： 日本 ,  肺癌 ,  症例 ,  癌 ,  リスク ,  薬物代謝 ,  酵素遺伝子 ,  CYP2A6 ,  CYP4B1 ,  GSTM1 ,  GSTT1 ,  多型 ,  関連性