Art

J-GLOBAL ID：201102289975232352   Reference number：11A1301058

A novel l-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid

潜在的インシュリン性及び抗肥満アミノ酸,(2S,3R,4S)-4-ヒドロキシイソロイシン産生Bacillus thuringiensisでの新規L-イソロイシン代謝

Author (13)： OGAWA Jun (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  OGAWA Jun (Kyoto Univ., Res. Div. of Microbial Sciences, Kitashirakawa-oiwakecho, Sakyo-ku, 606-8502, Kyoto, JPN) ,  KODERA Tomohiro (Ajinomoto Co., Inc, Inst. of Life Sciences, Suzuki-cho, Kawasaki-ku, 210-8681, Kawasaki, JPN) ,  SMIRNOV Sergey V. (Ajinomoto-Genetika Res. Inst., 1st Dorozhny pr. 1, 113545, Moscow, RUS) ,  HIBI Makoto (Kyoto Univ., Lab. of Industrial Microbiology, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  SAMSONOVA Natalia N. (Ajinomoto-Genetika Res. Inst., 1st Dorozhny pr. 1, 113545, Moscow, RUS) ,  KOYAMA Ryoukichi (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  YAMANAKA Hiroyuki (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  MANO Junichi (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  KAWASHIMA Takashi (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  YOKOZEKI Kenzo (Kyoto Univ., Lab. of Industrial Microbiology, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...) ,  YOKOZEKI Kenzo (Ajinomoto Co., Inc, Aminoscience Laboratories, Suzuki-cho, Kawasaki-ku, 210-8681, Kawasaki, JPN) ,  SHIMIZU Sakayu (Kyoto Univ., Div. of Applied Life Sciences, Graduate School of Agriculture, Kitashirakawa-oiwakecho, Sakyo-ku ...)
Material： Applied Microbiology and Biotechnology  (Appl Microbiol Biotechnol)
Volume： 89  Issue： 6  Page： 1929-1938  Publication year： Mar. 2011 
JST Material Number： H0764A  ISSN： 0175-7598  CODEN： EJABDD  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： pharmacological action ,  amino acid ,  Bacillus thuringiensis ,  *amino acid metabolism ,  *aliphatic carboxylic acid ,  dioxygenase ,  dehydrogenase ,  citric acid cycle ,  vitamin B12 ,  *metabolic pathway ,  aliphatic amine ,  branched-chain amino acid ,  primary amine ,  insulin
Semi thesaurus term： insulin ,  *(2S,3R,4S)-4-ヒドロキシイソロイシン ,  L-イソロイシン代謝 ,  NAD⁺依存デヒドロゲナーゼ ,  α-ケトグルタル酸依存ジオキシゲナーゼ ,  anti obesity effect

JST classification (2)： Enzyme in general  (EB09010D) ,  Metabolism and nutrition  (EG03054K)

Substance index (4)： (2S,3R)-2-Amino-3-methyl-4-oxopentanoic acid ,  2-Amino-3-methyl-4-oxopentanoic acid ,  4-Hydroxyisoleucine ,  Isoleucine

Terms in the title (8)： インシュリン ,  肥満 ,  アミノ酸 ,  3R ,  4-ヒドロキシイソロイシン ,  Bacillus ,  L-イソロイシン ,  代謝