ISHIZAWA Michiyasu

イシザワミチヤス | ISHIZAWA Michiyasu

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Medical biochemistry

Research keywords (3)： bile acid , vitamin D , nuclear receptor

Research theme for competitive and other funds (6)：

2016 - 2019 肥満モデルマウスの腸内環境及び胆汁酸代謝変動におけるビタミンD受容体の役割
2013 - 2016 Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
2015 - 2016 Analysis of the effects of novel structural vitamin D derivatives to mice.
2014 - 2016 肥満モデルマウスにおけるビタミンDシグナルと胆汁酸代謝の関係
2010 - 2012 Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells

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Papers (26)：

Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada. Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D3 Derivatives with Structure-Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs. Biomolecules. 2023. 13. 7. 1082-1082
Kubota H, Ishizawa M, Kodama M, Nagase Y, Kato S, Makishima M, Sakurai K. Vitamin D receptor mediates attenuating effect of lithocholic acid on dextran sulfate sodium induced colitis in mice. International Journal of Molecular Sciences. 2023. in press
Yoshihara A, Kawasaki H, Masuno H, Takada K, Numoto N, Ito N, Hirata N, Kanda Y, Ishizawa M, Makishima M, et al. Lithocholic acid amides as potent vitamin D receptor agonists. Biomolecules. 2022. 12. 1. 130
Adachi K, Ishizawa M, Uno S, Kubota H, Henmi T, Koshinaga T, Makishima M, Sakurai K. Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice. Chem Biol Interact. 2022. 353. 109802
Ishizawa Μ, Hirayu Α, Makishima Μ. Zinc inhibits cadherin 1 expression induced by 1α,25-dihydroxyvitamin D3 in colon cancer cells. Anticancer Research. 2021. 41. 11. 5453-5459

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MISC (8)：

Nishida Shigeru, Ishizawa Michiyasu, Kato Shigeaki, Makishima Makoto. Vitamin D receptor deletion changes bile acid composition in mice orally administered chenodeoxycholic acid. J Nutr Sci Vitaminol. 2020. 66. 4. 370-374
Ishizawa Michiyasu, Akagi Daisuke, Yamamoto Jumpei, Makishima Makoto. 1α,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. J Steroid Biochem Mol Biol. 2017. 172. 55-61
坂根里枝, 石澤通康, 木村キミト, 大西創, 廣田佳久, 中川公恵, 岡野登志夫, 槇島誠, 須原義智. ニューロンへの分化を誘導する新規ビタミンK誘導体の合成と簡便な活性評価法の検討. 日本薬学会年会要旨集. 2015. 135th. 2. 246-246
石澤通康, 高野真史, 橘高敦史, 坂根里枝, 須原義智, 山田幸子, 槇島誠. 1. 細胞選択的及び遺伝子選択的活性を有するビタミンD誘導体の生物活性評価(研究発表,第344回会議研究発表要旨,脂溶性ビタミン総合研究委員会). ビタミン. 2015. 89. 1. 39-40
Sakane Rie, Kimura Kimito, Hirota Yoshihisa, Nakagawa Kimie, Ishizawa Michiyasu, Makishima Makoto, Wada Akimori, Okano Toshio, Suhara Yoshitomo. Exploring of Vitamin K Analogues Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells. Symposium on the Chemistry of Natural Products, symposium papers. 2015. 57. 0. PosterP51

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Patents (1)：

Lectures and oral presentations (99)：

The role of vitamin D receptor in the suppressive effects of lithocholic acid on murine colitis.
(2023)
ビタミンD活性を有する胆汁酸誘導体の構造活性相関
(日本ビタミン学会第75回大会 2023)
炎症性腸疾患モデルマウスにおけるリトコール酸のビタミンD受容体を介した効果
(第43回胆汁酸研究会 2022)
リトコール酸のビタミンD受容体を介した炎症性腸疾患抑制効果
(日本ビタミン学会第74回大会 2022)
ビタミンD受容体は胆汁酸の大腸炎抑制効果に関与する
(第 371 回脂溶性ビタミン総合研究委員会 2022)

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Education (1)：

2008 - 2012 Nihon University Graduate School, Division of Medicine major in pathological metabology

Work history (6)：

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Awards (1)：

Association Membership(s) (6)：

日本ビタミン学会 , 日本分子生物学会 , 日本生化学会 , 日本レチノイド研究会 , 日本宇宙航空環境医学会 , 日本宇宙生物科学会

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