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J-GLOBAL ID：201202236385466766   Reference number：12A0056493

Embryonic Lethality in Mice Lacking Mismatch-Specific Thymine DNA Glycosylase Is Partially Prevented by DOPS, a Precursor of Noradrenaline

マウスにおけるミスマッチのない胚致死性-特異的チミンDNAグリコシラーゼは,ノルアドレナリンの前駆物質であるDOPSによって部分的に防御される

Author (8)： SAITO Yusuke (Dep. of Cell Biology, Graduate School of Medicine, Tohoku Univ.) ,  ONO Tetsuya (Dep. of Cell Biology, Graduate School of Medicine, Tohoku Univ.) ,  TAKEDA Naoki (Center for Animal Resources and Dev., Kumamoto Univ.) ,  NOHMI Takehiko (Div. of Genetics and Mutagenesis, National Inst. of Health Sciences) ,  SEKI Masayuki (Molecular Cell Biology Lab., Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  ENOMOTO Takemi (Molecular Cell Biology Lab., Res. Inst. of Pharmaceutical Sciences, Fac. of Pharmacy, Musashino Univ.) ,  NODA Tetsuo (Genome Center, Japanese Foundation for Cancer Res.) ,  UEHARA Yoshihiko (Dep. of Cell Biology, Graduate School of Medicine, Tohoku Univ.)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 226  Issue： 1  Page： 75-83 (J-STAGE)  Publication year： 2012 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： variation(biology) ,...

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JST classification (1)： Genetic variation  (EC01030Y)

Substance index (4)： Norepinephrine ,  Droxidopa ,  5-Methylcytosine ,  Cytosine

Reference (27)：

• CORTAZAR, D. Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature. 2011, 470, 419-423
• CORTELLINO, S. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011, 146, 67-79
• DE BOER, J. G. Spontaneous mutation in lacI transgenic mice : a comparison of tissues. Mutagenesis. 1998, 13, 109-114
• GALLINARI, P. A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Nature. 1996, 383, 735-738
• GONZALGO, M. L. Mutagenic and epigenetic effects of DNA methylation. Mutat. Res. 1997, 386, 107-118

Terms in the title (9)： マウス ,  ミスマッチ ,  胚 ,  致死性 ,  チミンDNAグリコシラーゼ ,  ノルアドレナリン ,  前駆物質 ,  DOPS ,  防御