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J-GLOBAL ID：201202254618697141   Reference number：12A1774264

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

グリオトキシンおよび関連エピポリチオジオキソピペラジン類によるヒストンH3K9メチルトランスフェラーゼの阻害

Author (15)： TAKAHASHI Masanari (RIKEN Advanced Sci. Inst., Wako, JPN) ,  TAKAHASHI Masanari (Tokyo Denki Univ., Chiyoda-ku, JPN) ,  TAKEMOTO Yasushi (RIKEN Advanced Sci. Inst., Wako, JPN) ,  SHIMAZU Tadahiro (RIKEN Advanced Sci. Inst., Wako, JPN) ,  KAWASAKI Hisashi (Tokyo Denki Univ., Chiyoda-ku, JPN) ,  TACHIBANA Makoto (Kyoto Univ., Kyoto, JPN) ,  SHINKAI Yoichi (RIKEN Advanced Sci. Inst., Wako, JPN) ,  SHINKAI Yoichi (Kyoto Univ., Kyoto, JPN) ,  TAKAGI Motoki (Japan Biological Informatics Consortium (JBIC), Koto-ku, JPN) ,  SHIN-YA Kazuo (National Inst. of Advanced Industrial Sci. and Technol., Koto-ku, JPN) ,  IGARASHI Yasuhiro (Toyama Prefectural Univ., Imizu, JPN) ,  ITO Akihiro (RIKEN Advanced Sci. Inst., Wako, JPN) ,  ITO Akihiro (JST-CREST, Kawaguchi, JPN) ,  YOSHIDA Minoru (RIKEN Advanced Sci. Inst., Wako, JPN) ,  YOSHIDA Minoru (JST-CREST, Kawaguchi, JPN)
Material： Journal of Antibiotics (Web)  (J Antibiot (Web))
Volume： 65  Issue： 5  Page： 263-265 (WEB ONLY)  Publication year： May. 2012 
JST Material Number： U0320A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： bioactive factor ,...
Semi thesaurus term： エピポリチオジオキソピペラジン ,...

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JST classification (1)： Antibiotics in general  (GX01000E)

Substance index (4)： 19,19′-Dideoxychetocin ,  Gliotoxin ,  Chaetomin ,  Bisdethiobis(methylthio)acetylgliotoxin

Reference (18)：

• 1 Noma, K., Allis, C. D. & Grewal, S. I. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293, 1150-1155 (2001).
• 2 Tachibana, M., Sugimoto, K., Fukushima, T. & Shinkai, Y. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276, 25309-25317 (2001).
• 3 Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyl-transferases. Nature 406, 593-599 (2000).
• 4 Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 19, 815-826 (2005).
• 5 Bayl in, S. B. & Ohm, J. E. Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer 6, 107-116 (2006).

Terms in the title (3)： グリオトキシン ,  メチルトランスフェラーゼ ,  阻害