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J-GLOBAL ID：201202255050307277   Reference number：12A1681193

RecQ5 Interacts with Rad51 and Is Involved in Resistance of Drosophila to Cisplatin Treatment

RecQ5はRad51と相互作用しシスプラチン処置に対するDrosophilaの耐性に関与する

Author (13)： MARUYAMA Sayako (Cellular and Molecular Biology Lab., RIKEN) ,  OHKITA Noriko (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  NAKAYAMA Minoru (Cellular and Molecular Biology Lab., RIKEN) ,  NAKAYAMA Minoru (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  AKABOSHI Eiko (Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka Univ.) ,  SHIBATA Takehiko (Cellular and Molecular Biology Lab., RIKEN) ,  FUNAKOSHI Eishi (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  FUNAKOSHI Eishi (Div. of Molecular Biology, Dep. of Life Sci., Fac. of Sci. and Engineering, Setsunan Univ.) ,  TAKEUCHI Kenji (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  ITO Fumiaki (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  KAWASAKI Katsumi (Cellular and Molecular Biology Lab., RIKEN) ,  KAWASAKI Katsumi (Div. of Biochemistry, Graduate School of Pharmaceutical Sciences, Setsunan Univ.) ,  KAWASAKI Katsumi (Div. of Molecular Biology, Dep. of Life Sci., Fac. of Sci. and Engineering, Setsunan Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 35  Issue： 11  Page： 2017-2022 (J-STAGE)  Publication year： 2012 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： ATPase ,...
Semi thesaurus term： BLM ,...

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JST classification (4)： Proteins and peptides in general  (EB03010N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Enzyme in general  (EB09010D) ,  Molecular genetics in general  (EC02010J)

Reference (40)：

• 1) Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev., 21, 3073–3084 (2007).
• 2) Nakayama M, Yamaguchi S, Sagisu Y, Sakurai H, Ito F, Kawasaki K. Loss of RecQ5 leads to spontaneous mitotic defects and chromosomal aberrations in Drosophila melanogaster. DNA Repair, 8, 232–241 (2009).
• 3) Sakurai H, Okado M, Ito F, Kawasaki K. Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos. FEBS Lett., 585, 1923–1928 (2011).
• 4) Takada S, Kelkar A, Theurkauf WE. Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell, 113, 87–99 (2003).
• 5) Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA Repair and Mutagenesis, ASM Press, Washington, D.C. (2006).

Terms in the title (6)： Rad51 ,  相互作用 ,  シスプラチン ,  処置 ,  Drosophila ,  耐性