Art

J-GLOBAL ID：201202257191186581   Reference number：12A0616913

Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence

ヒトステロイド及び生体異物受容体リガンド結合ドメイン配列の相同ノックインによるヒト化ステロイド及び生体異物受容体マウスの開発

Author (12)： IGARASHI Katsuhide (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  KITAJIMA Satoshi (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  AISAKI Ken-ichi (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  TANEMURA Kentaro (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  TAQUAHASHI Yuhji (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  MORIYAMA Noriko (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  IKENO Eriko (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  MATSUDA Nae (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences) ,  SAGA Yumiko (Div. of Mammalian Dev., National Inst. of Genetics) ,  SAGA Yumiko (The Graduate Univ. for Advanced Studies (Sokendai)) ,  BLUMBERG Bruce (Dep. of Developmental and Cell Biology, 2011 Biological Sciences 3, Univ. of California) ,  KANNO Jun (Div. of Cellular and Molecular Toxicology, Biological Safety Res. Center, National Inst. of Health Sciences)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 37  Issue： 2  Page： 373-380 (J-STAGE)  Publication year： 2012 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Cytochrome P-450 CYP3A ,...

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JST classification (3)： Laboratry organisms  (EA03070Y) ,  Receptors on cell membrane  (EF04030C) ,  Gene manipulation  (EC02050B)

Substance index (1)： Rifampin

Reference (19)：

• AOUABDI, S. Transcriptional regulation of the PXR gene : identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter or PXR. Drug Metab. Dispos. 2006, 34, 138-144
• BERTILSSON, G. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci., USA. 1998, 95, 12208-12213
• BLUMBERG, B. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes. Dev. 1998, 12, 3195-3205
• JUNG, D. Pregnane X receptor is a target of farnesoid X receptor. J. Biol. Chem. 2006, 281, 19081-19091
• KANNO, J. "Per cell" normalization method for mRNA measurement by quantitative PCR and microarrays. BMC genomics. 2006, 7, 64

Terms in the title (9)： ヒト ,  ステロイド ,  生体異物 ,  受容体リガンド ,  結合ドメイン ,  ノック ,  受容体 ,  マウス ,  開発