Art

J-GLOBAL ID：201202289545672488   Reference number：12A1673200

Therapeutic targets in the ASK1-dependent stress signaling pathways

ASK1-依存性ストレスシグナル伝達経路の治療標的

Author (5)： HAYAKAWA Ryoichi (Lab. of Cell Signaling, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo) ,  HAYAKAWA Teruyuki (Lab. of Cell Signaling, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo) ,  TAKEDA Kohsuke (Lab. of Cell Signaling, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo) ,  TAKEDA Kohsuke (Div. of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki Univ.) ,  ICHIJO Hidenori (Lab. of Cell Signaling, Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo)
Material： Proceedings of the Japan Academy. Series B. Physical and Biological Sciences  (日本学士院紀要 B)
Volume： 88  Issue： 8  Page： 434-453 (J-STAGE)  Publication year： 2012 
JST Material Number： G0485B  ISSN： 0386-2208  CODEN： PJABDW  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *protein kinase ,...
Semi thesaurus term： *ASK1 ,...

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JST classification (1)： Cell physiology in general  (EF02010S)

Reference (147)：

• 1) Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K. and Gotoh, Y. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90–94.
• 2) Takeda, K., Noguchi, T., Naguro, I. and Ichijo, H. (2008) Apoptosis signal-regulating kinase 1 in stress and immune response. Annu. Rev. Pharmacol. Toxicol. 48, 199–225.
• 3) Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H. (2011) Apoptosis signaling kinases: from stress response to health outcomes. Antioxid. Redox Signal. 15, 719–761.
• 4) Guo, X., Harada, C., Namekata, K., Matsuzawa, A., Camps, M., Ji, H., Swinnen, D., Jorand-Lebrun, C., Muzerelle, M., Vitte, P.A., Ruckle, T., Kimura, A., Kohyama, K., Matsumoto, Y., Ichijo, H. and Harada, T. (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol. Med. 2, 504–515.
• 5) Bogoyevitch, M.A., Ngoei, K.R., Zhao, T.T., Yeap, Y.Y. and Ng, D.C. (2010) c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges. Biochim. Biophys. Acta 1804, 463–475.

Terms in the title (4)： 依存性 ,  ストレス ,  シグナル伝達経路 ,  治療標的