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J-GLOBAL ID：201302212115536356   Reference number：13A1299189

Structure-Activity Relationship Study and Total Synthesis of Pyripyropene A as a Potent ACAT2-Selective Inhibitor

新規脂質異常症予防治療薬を指向したACAT2選択的阻害剤ピリピロペンAの構造活性相関研究

Author (5)： OTAWA MASAKI (北里大 薬) ,  OMURA SATOSHI (北里大 北里生命科研) ,  TOMODA HIROSHI (北里大 薬) ,  NAGAMITSU TOORU (北里大 薬) ,  NAGAMITSU TOORU (北里大 大学院薬学研究科)
Material： 有機合成化学協会誌  (Journal of Synthetic Organic Chemistry, Japan)
Volume： 71  Issue： 8  Page： 830-843  Publication year： Aug. 01, 2013 
JST Material Number： F0383A  ISSN： 0037-9980  CODEN： YGKKAE  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： sterol O-acyltransferase ,...
Semi thesaurus term： ACAT-2

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JST classification (2)： Synthesis of drugs  (GV01030F) ,  Condensed derivatives of pyrane  (CF07093I)

Substance index (9)： Pyripyropene A ,  6-Oxo-6H-pyran-3-carboxylic acid (3S)-3α-acetoxy-4β-(acetoxymethyl)-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  Pyrazine-2-carboxylic acid (3S)-3α-acetoxy-4β-(acetoxymethyl)-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  4-Cyanobenzoic acid (3S)-3α,4β-[oxy(di-tert-butylsilylene)oxymethylene]-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  4-Cyanobenzoic acid (3S)-3α-(di-tert-butylfluorosilyl)-4β-(hydroxymethyl)-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  4-Cyanobenzoic acid (3S)-3α,12α-dihydroxy-4β-[(di-tert-butylfluorosiloxy)methyl]-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  4-Cyanobenzoic acid (3S)-3α,12α-dihydroxy-4β-(hydroxymethyl)-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  Pentanoic acid (3S)-3α,4β-[oxy[(R)-propane-1,1-diyl]oxymethylene]-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester ,  4-Cyanobenzoic acid (3S)-3α,4β-[oxy[(R)-phenylmethylene]oxymethylene]-11-oxo-1,3,4,4aβ,5,6,6a,12,12aβ,12b-decahydro-12α-hydroxy-4,6aα,12bα-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6α-yl ester

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Terms in the title (7)： 脂質異常症 ,  予防治療 ,  ACAT2 ,  阻害剤 ,  ピリピロペンA ,  構造活性相関 ,  研究