Art

J-GLOBAL ID：201402203325583509   Reference number：14A0393063

Effects of Oral Administration of Non-genotoxic Hepato-hypertrophic Compounds on Metabolic Potency of Rat Liver

ラット肝臓の代謝能力に及ぼす非遺伝毒性肝臓肥大性化合物の経口投与の影響

Author (10)： FANG Xing (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  NUNOSHIBA Tatsuo (International Christian Univ.) ,  YOSHIDA Midori (National Inst. of Health Sciences) ,  NISHIKAWA Akiyoshi (National Inst. of Health Sciences) ,  NEMOTO Kiyomitsu (School of Pharmaceutical Sciences, Univ. of Shizuoka) ,  DEGAWA Masakuni (School of Pharmaceutical Sciences, Univ. of Shizuoka) ,  ARIMOTO Sakae (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  OKAMOTO Keinosuke (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  TAKAHASHI Eizo (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.) ,  NEGISHI Tomoe (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ.)
Material： Genes and Environment  (Genes Environ)
Volume： 36  Issue： 1  Page： 1-9 (J-STAGE)  Publication year： 2014 
JST Material Number： X0839A  ISSN： 1880-7046  CODEN： GEENGP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *liver disease ,...
Semi thesaurus term： EROD (enzyme) ,...

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JST classification (1)： Carcinogenic mechanisms and factors  (GE02020C)

Substance index (3)： MeIQx ,  Dimethylnitrosamine ,  Benzo(a)pyrene

Reference (35)：

• 1 Grasso P, Hinton RH. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver. Mutat Res. 1991; 248: 271-90.
• 2 Davies TS, Monro A. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am Coll Toxicol. 1995; 14: 90-107.
• 3 Gold LS, Manley NB, Slone TH, Rohrbach L, Garfinkel GB. Supplement to the Carcinogenic Potency Database (CPDB): Results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998. Toxicol Sci. 2005; 85: 747-808.
• 4 Lin JH. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res. 2006; 23: 1089-116.
• 5 Takahashi O, Oishi S, Fujitani T, Tanaka T, Yoneyama M. Chronic toxicity studies of piperonyl butoxide in F344 rats: induction of hepatocellular carcinoma. Fundam Appl Toxicol. 1994; 22: 293-303.

Terms in the title (7)： ラット ,  肝臓 ,  代謝 ,  能力 ,  遺伝毒性 ,  肥大 ,  経口投与