Art

J-GLOBAL ID：201402205270609115   Reference number：14A0468207

Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

結合組織疾患患者におけるCYP3A5多型性とタクロリムスの血液濃度の間の有意な相関

Author (12)： TANAKA Kosuke (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  TERAO Chikashi (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  OHMURA Koichiro (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  TAKAHASHI Meiko (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  NAKASHIMA Ran (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  IMURA Yoshitaka (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  YOSHIFUJI Hajime (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  YUKAWA Naoichiro (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  USUI Takashi (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  FUJII Takao (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  MIMORI Tsuneyo (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN) ,  MATSUDA Fumihiko (Kyoto Univ. Graduate School of Medicine, Kyoto, JPN)
Material： Journal of Human Genetics  (J Hum Genet)
Volume： 59  Issue： 2  Page： 107-109  Publication year： Feb. 2014 
JST Material Number： Z0756A  ISSN： 1434-5161  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *connective tissue disease ,...
Semi thesaurus term： CYP3A5 ,...

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JST classification (4)： Musculoskeletal system diagnosis  (GG02000M) ,  Molecular genetics in general  (EC02010J) ,  Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Epidemiology  (GB03000E)

Substance index (1)： Tacrolimus

Reference (20)：

• Kino, T., Hatanaka, H., Miyata, S., Inamura, N., Nishiyama, M., Yajima, T. et al. FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immuno-suppressive effect of FK-506 in vitro. J. Antibiot. (Tokyo) 40, 1256-1265 (1987).
• Scott, L. J., McKeage, K., Keam, S. J. & Plosker, G. L. Tacrolimus: a further update of its use in the management of organ transplantation. Drugs 63, 1247-1297 (2003).
• Takeuchi, T., Kawai, S., Yamamoto, K., Harigai, M., Ishida, K. & Miyasaka, N. Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis. Mod. Rheumatol. 24, 8-16 (2014).
• Takahashi, S., Hiromura, K., Sakurai, N., Matsumoto, T., Ikeuchi, H., Maeshima, A. et al. Efficacy and safety of tacrolimus for induction therapy in patients with active lupus nephritis. Mod. Rheumatol. 21, 282-289 (2011).
• Hesselink, D. A., van Gelder, T. & van Schaik, R. H. The pharmacogenetics of calcineurin inhibitors: one step closer toward individualized immunosuppression? Pharmacogenomics 6, 323-337 (2005).

Terms in the title (7)： 結合組織疾患 ,  患者 ,  CYP3A5 ,  多型性 ,  タクロリムス ,  血液 ,  相関