Art

J-GLOBAL ID：201502208270288766   Reference number：15A1024799

Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals

オキソモルギン,核因子κBシグナルを含むリポ多糖類誘発一酸化窒素産生の有望な抑制剤

Author (11)： MORITA Hiroshi (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  NISHINO Hitomi (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  NAKAJIMA Yuki (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  KAKUBARI Yoshiaki (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  NAKATA Asami (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  DEGUCHI Jun (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  NUGROHO Alfarius Eko (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  HIRASAWA Yusuke (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  KANEDA Toshio (Hoshi Univ., Fac. of Pharmaceutical Sciences, Ebara 2-4-41 Shinagawa-ku, 142-8501, Tokyo, JPN) ,  KAWASAKI Yoko (National Inst. of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501, Tokyo, JPN) ,  GODA Yukihiro (National Inst. of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501, Tokyo, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 69  Issue： 4  Page： 608-611  Publication year： Oct. 2015 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： NF-kappaB ,...
Semi thesaurus term： Rubia tinctorum ,...

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JST classification (1)： Crude drugs in general  (GX06010Y)

Substance index (2)： Oxomollugin ,  Mollugin

Reference (19)：

• Itokawa H, Qiao Y, Takeya K (1989) Anthraquinones and naphthohydroquinones from Rubia cordifolia. Phytochemistry 28:3465-3468
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• Kawasaki Y, Goda Y, Yoshihira K (1992) The mutagenic constituents of Rubia tinctorum. Chem Pharm Bull 40:1504-1509
• Lu Y, Liu R, Sun C, Pan Y (2007) An effective high-speed countercurrent chromatographic method for preparative isolation and purification of mollugin directly from the ethanol extract of the Chinese medicinal plant Rubia cordifolia. J Sep Sci 30:1313-1317
• Yamasaki F, Machida S, Nakata A, Nugroho AE, Hirasawa Y, Kaneda T, Shirota O, Hagane N, Sugizaki T, Morita H (2013) Haworforbins A-C, new phenolics from Haworthia cymbiformis. J Nat Med 67:212-216

Terms in the title (6)： 核因子κB ,  シグナル ,  リポ多糖類 ,  誘発 ,  一酸化窒素 ,  抑制剤