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J-GLOBAL ID：201502215369521612   Reference number：15A0830735

CYP7A1遺伝子多型が影響する原発性胆汁性肝硬変進行メカニズムの解明

Author (4)： INAMINE TATSUO (長崎大 大学院医歯薬学総合研究科 薬物治療学分野) ,  NAKAMURA MINORU (長崎大 大学院医歯薬学総合研究科 先端医療学分野) ,  NAKAMURA MINORU (長崎医療セ 臨床研究セ) ,  TSUKAMOTO KAZUHIRO (長崎大 大学院医歯薬学総合研究科 薬物治療学分野)
Material： 臨床薬理の進歩  (Recent Advances in Clinical Pharmacology)
Issue： 36  Page： 91-99  Publication year： Jun. 25, 2015 
JST Material Number： Y0720A  ISSN： 0914-4366  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CYP7A1 ,...

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JST classification (2)： Digestive system diseases  (GH03000W) ,  Molecular genetics in general  (EC02010J)

Substance index (1)： Ursodeoxycholic Acid

Reference (13)：

• Hirschfield GM, Invernizzi P. Progress in the genetics of primary biliary cirrhosis. Semin Liver Dis 2011; 31: 147-56.
• Aiba Y, Nakamura M, Joshita S, et al. PBC Study Group in NHOSLJ. Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients. J Gastroenterol 2011; 46: 1203-12.
• Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, Komori A, Omagari K, Ishibashi H, Tsukamoto K. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 2008; 48: 853-62.
• Poupon R, Ping C, Chrétien Y, et al. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. J Hepatol 2008; 49: 1038-45.
• Inamine T, Higa S, Noguchi F, Kondo S, Omagari K, Yatsuhashi H, Tsukamoto K, Nakamura M. Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients. J Gastroenterol 2013; 48: 1160-70.

Terms in the title (4)： CYP7A1 ,  遺伝子多型 ,  原発性胆汁性肝硬変 ,  メカニズム