Art

J-GLOBAL ID：201102213080040036   Reference number：11A1754208

Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients

CTLA4とSLC4A2の遺伝子多型は日本人患者の原発性胆汁性肝硬変の病因に異なって関連している

Author (35)： AIBA Yoshihiro (Nagasaki Medical Center, Nagasaki, JPN) ,  NAKAMURA Minoru (Nagasaki Medical Center, Nagasaki, JPN) ,  NAKAMURA Minoru (Nagasaki Univ. Graduate School of Biomedical Sci., Omura, JPN) ,  NAKAMURA Minoru (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  JOSHITA Satoru (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  INAMINE Tatsuo (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  KOMORI Atsumasa (Nagasaki Medical Center, Nagasaki, JPN) ,  KOMORI Atsumasa (Nagasaki Univ. Graduate School of Biomedical Sci., Omura, JPN) ,  YOSHIZAWA Kaname (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  UMEMURA Takeji (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  HORIE Hitomi (Nagasaki Medical Center, Nagasaki, JPN) ,  MIGITA Kiyoshi (Nagasaki Medical Center, Nagasaki, JPN) ,  MIGITA Kiyoshi (Nagasaki Univ. Graduate School of Biomedical Sci., Omura, JPN) ,  YATSUHASHI Hiroshi (Nagasaki Medical Center, Nagasaki, JPN) ,  YATSUHASHI Hiroshi (Nagasaki Univ. Graduate School of Biomedical Sci., Omura, JPN) ,  NAKAMUTA Makoto (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  FUKUSHIMA Nobuyoshi (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  SAOSHIRO Takeo (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  HAYASHI Shigeki (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  KOUNO Hiroshi (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  OTA Hajime (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  MURO Toyokichi (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  WATANABE Yukio (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  NAKAMURA Yoko (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  KOMEDA Toshiki (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  SHIMADA Masaaki (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  MASAKI Naohiko (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  KOMATSU Tatsuji (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  YAGURA Michiyasu (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  SUGI Kazuhiro (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  KOGA Michiaki (PBC Study Group in National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Omura, JPN) ,  TSUKAMOTO Kazuhiro (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  TANAKA Eiji (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  ISHIBASHI Hiromi (Nagasaki Medical Center, Nagasaki, JPN) ,  ISHIBASHI Hiromi (Nagasaki Univ. Graduate School of Biomedical Sci., Omura, JPN)
Material： Journal of Gastroenterology  (J Gastroenterol)
Volume： 46  Issue： 10  Page： 1203-1212  Publication year： 2011 
JST Material Number： Z0748A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *CTLA4 ,...

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JST classification (1)： Digestive system diseases  (GH03000W)

Reference (35)：

• SELMI, C. Primary biliary cirrhosis in monozygotic and dizygotic twins : genetics, epigenetics, and environment. Gastroenterology. 2004, 127, 485-492
• DONALDSON, PT. HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis : a large-scale study. Hepatology. 2006, 44, 667-674
• NAKAMURA, M. Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC) : the HLA-DRB1 polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC. Hepatol Res. 2010, 40, 494-504
• FAN, LY. Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population. World J Gastroenterol. 2004, 10, 3056-3059
• INVERNIZZI, P. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis : a multicenter study of 664 patients and 1992 healthy controls. Hepatology. 2008, 48, 1906-1912

Terms in the title (6)： CTLA4 ,  遺伝子多型 ,  日本人 ,  患者 ,  原発性胆汁性肝硬変 ,  病因