Art

J-GLOBAL ID：201502216925687971   Reference number：15A0859045

Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

自己抗体状態と組織学的変数は原発性胆汁性肝硬変の日本人患者における治療への生化学的応答と長期転帰に影響を及ぼす

Author (26)： NAKAMURA Minoru ,  KONDO Hisayoshi (Atomic Bomb Disease Inst., Nagasaki Univ. Graduate School of Biomedical Sciences, Nagasaki, JPN) ,  TANAKA Atsushi (Dep. of Medicine, Teikyo Univ. School of Medicine, Tokyo, JPN) ,  KOMORI Atsumasa (Clinical Res. Center in National Hospital Organization (NHO) Nagasaki Medical Center and Dep. of Hepatology ...) ,  ITO Masahiro (Clinical Res. Center in National Hospital Organization (NHO) Nagasaki Medical Center and Dep. of Hepatology ...) ,  YAMAMOTO Kazuhide (Dep. of Gastroenterology and Hepatology, Okayama Univ. Graduate School of Medicine, Dentistry and Pharmaceutical ...) ,  OHIRA Hiromasa (Dep. of Gastroenterology and Rheumatology, Fukushima Medical Univ. School of Medicine, Fukushima, JPN) ,  ZENIYA Mikio (Div. of Gastroenterology and Hepatology, Tokyo Jikei Univ. School of Medicine, Tokyo, JPN) ,  HASHIMOTO Etsuko (Dep. of Medicine and Gastroenterology, Tokyo Women’s Medical Univ., Tokyo, JPN) ,  HONDA Masao (Dep. of Gastroenterology, Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  KANEKO Shuichi (Dep. of Gastroenterology, Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  UENO Yoshiyuki (Div. of Gastroenterology, Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  KIKUCHI Kentaro (Dep. of Internal Medicine, Teikyo Univ. Mizonokuchi Hospital, Kawasaki, JPN) ,  SHIMODA Shinji (Dep. of Medicine and Biosystemic Sci., Kyushu Univ. Graduate School of Medical Sciences, Fukuoka, JPN) ,  HARADA Kenichi (Dep. of Human Pathology, Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  ARAI Kuniaki (Dep. of Gastroenterology, Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  MIYAKE Yasuhiro (Dep. of Medicine, Teikyo Univ. School of Medicine, Tokyo, JPN) ,  ABE Masanori (Dep. of Gastroenterology and Metabology, Ehime Univ. Graduate School of Medicine, Matsuyama, JPN) ,  TANIAI Makiko (Dep. of Medicine and Gastroenterology, Tokyo Women’s Medical Univ., Tokyo, JPN) ,  SAIBARA Toshiji (Dep. of Gastroenterology and Hepatology, Kochi Medical School, Kochi, JPN) ,  SAKISAKA Shotaro (Dep. of Gastroenterology and Medicine, Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  TAKIKAWA Hajime (Dep. of Medicine, Teikyo Univ. School of Medicine, Tokyo, JPN) ,  ONJI Morikazu (Dep. of Gastroenterology and Metabology, Ehime Univ. Graduate School of Medicine, Matsuyama, JPN) ,  TSUBOUCHI Hirohito (Dep. of Digestive and Lifestyle-related Disease, Kagoshima Univ. Graduate School of Medical and Dental Sci. ...) ,  NAKANUMA Yasuni (Dep. of Human Pathology, Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  ISHIBASHI Hiromi (Clinical Res. Center in National Hospital Organization (NHO) Nagasaki Medical Center and Dep. of Hepatology ...)
Material： Hepatology Research  (Hepatol Res)
Volume： 45  Issue： 8  Page： 846-855  Publication year： Aug. 2015 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： long term outcome

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JST classification (1)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (2)： Ursodeoxycholic Acid ,  Bezafibrate

Reference (32)：

• Poupon R. Primary biliary cirrhosis: a 2010 update. Hepatol 2010; 52: 745-58.
• Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa N, Heathcote EJ. AASLD practice guidelines: primary biliary cirrhosis. Hepatology 2009; 50: 291-308.
• European Association for the Study of the liver. EASL clinical practice guidelines: management of cholestatic liver diseases. J Hepatol 2009; 51: 237-67.
• Degott C, Zafrani ES, Callard P, Balkau B, Poupon RE, Poupon R. Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression. Hepatology 1999; 29: 1007-12.
• Corpechot C, Carrat F, Poupon R, Poupon RE. Primary biliary cirrhosis: incidence and predictive factors of cirrhosis development in ursodiol-treated patients. Gastroenterology 2002; 122: 652-8.

Terms in the title (10)： 自己抗体 ,  組織学 ,  変数 ,  原発性胆汁性肝硬変 ,  日本人 ,  患者 ,  治療 ,  生化学 ,  応答 ,  長期転帰