Rchr
J-GLOBAL ID：201601011154242541
Update date: Apr. 21, 2026
Oshima Yusuke
オオシマ ユウスケ | Oshima Yusuke
Affiliation and department：
Job title：
Specially Appointed Professor
Other affiliations (2)：
Research field (2)：
Medical systems
, Biological, health, and medical informatics
Research keywords (8)：
Raman spectroscopy
, Biomedical photonics
, multiphoton excitation imaging
, Pediatric surgery
, gastroenterology
, cancer diagnosis and therapy
, bone and cartilage disease
, spine surgery
Research theme for competitive and other funds (21)：
- 2025 - 2028 Development of Raman cytometry for blood cancer diagnosis
- 2025 - 2028 Rejuvenation of Oocytes through a Fundamental Understanding of Aging
- 2025 - 2028 抗がん剤誘発皮膚色素沈着に対するαリポ酸誘導体を用いた治療開発
- 2025 - 2028 Development of Permanent Chemotherapy-Induced Alopecia Treatment Based on Cell Cycle Arresting Action of Alpha Lipoic Acid Derivatives
- 2024 - 2027 Development of AI-assisted laparoscopic surgical system with Raman spectroscopy for Hirschsprung's Disease
- 2024 - 2027 Novel photoimmunotherapy using light-sensitive drugs and ultrashort pulsed laser for peritoneal dissemination of cancer
- 2022 - 2025 オルガネラ改変に基づく加齢卵子の”質”改善法の開発
- 2021 - 2025 Development of practical techniques for Raman detection of human infectious virus
- 2021 - 2025 Development of practical techniques for Raman detection of human infectious virus
- 2021 - 2024 Principles for the development of an ultra-thin imaging system by the spectral encoding
- 2021 - 2024 Development of an intraoperative diagnosis for Hirschsprung's disease using optical biopsy technology
- 2021 - 2024 Development of new photo dynamic therapy for peritoneal dissemination of gastric cancer
- 2021 - 2024 Development of an intraoperative identification of the recurrent nerve based on Raman spectroscopy to improve the prognosis of esophageal cancer
- 2020 - 2023 Development of new treatment method for colorectal cancer based on cancer microenvironment control using anti-inflammatory light
- 2018 - 2021 Pathophysiology analysis and clinical application development of cartilage degenerative diseases based on label-free imaging technology
- 2018 - 2021 Raman spectroscopic study of cancer metastasis and diagnosis.
- 2016 - 2019 Label-free imaging technique based on nonlinear optics in biological tissues for medical application
- 2012 - 2015 Label-free imaging technique based on nonlinear optics in biological tissues for medical application
- 2012 - 2014 Nonliner optical imaging for deep tissue using hollow fiber bundle
- 2012 - 2014 Analysis of the TGF-b signaling in cartilage by nonlinear optics imaging combined with genetic engineering techniques
- 2007 - 2009 腫瘍診断のための顕微ラマンイメージング分光法の装置開発と性能評価
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Papers (65)：
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Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata. Association of HAMP Expression and CD8 + T-Cell Infiltration With Atezolizumab-Bevacizumab Response in Hepatocellular Carcinoma. Annals of Gastroenterological Surgery. 2026
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Yusuke Oshima, Yuki Matsumoto, Katsuhiro Ogawa, Kai Tamura, Rena Yagi, Noritaka Fujisawa, Takashi Katagiri, Shun Onishi, Hidefumi Shiroshita, Tsuyoshi Etho, et al. Label-free diagnostic procedure for hirschsprung’s disease to detect intestinal mucosal characteristics of aganglionosis by Raman spectroscopy with optimized decision algorithms. Lasers in Medical Science. 2025
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Akinori Taketani, Shota Koshiyama, Takayuki Haruki, Shota Yonezawa, Jun Tahara, Moe Yamazaki, Yusuke Oshima, Akinori Wada, Tsutomu Sato, Keiichi Koizumi, et al. Identification of the Cellular Tipping Point in the Inflammation Model of LPS-Induced RAW264.7 Macrophages Through Raman Spectroscopy and the Dynamical Network Biomarker Theory. Molecules. 2025
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Kosuke Hashimoto, Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Yusuke Oshima, Isao Kitajima, Hidetoshi Sato, Shigeru Saito. Identifying the crucial tipping point in the maturation process of cultured neurons using Raman spectroscopy and a dynamic network biomarker (DNB) analysis. Biochemical and Biophysical Research Communications. 2025. 743. 151167-151167
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Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Akinori Taketani, Yusuke Oshima, Makito Oku, Akinori Wada, Tsutomu Sato, Naoki Masuda, Jun Tahara, et al. Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis. International journal of molecular sciences. 2024. 25. 3
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MISC (135)：
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小川 雄大, 大嶋 佑介, 大西 峻, 白下 英史, 衛藤 剛, 家入 里志, 猪股 雅史. 光イメージング技術を用いたヒルシュスプルング病における無神経節腸管の形態学的解析. 日本小児外科学会雑誌. 2024. 60. 3. 508-508
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河野洋平, 長澤由依子, 相場崇行, 平塚孝宏, 大嶋祐介, 猪股雅史, 猪股雅史. 抗がん剤誘発脱毛における皮膚毛包周囲の変化と治療ターゲットの検討. 日本がんサポーティブケア学会学術集会プログラム・抄録集(CD-ROM). 2024. 9th
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CHEN Ziqian, 小山卓耶, 大嶋佑介, 片桐崇史. Calibration using structured illumination in spectral encoded imaging. 応用物理学会春季学術講演会講演予稿集(CD-ROM). 2024. 71st
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児玉佳祐, 小山卓耶, 大嶋佑介, 片桐崇史. Absorbance measurements in scattering media using ultrasonically induced virtual waveguide. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2024. 85th
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桐島潤, 小山卓耶, 大嶋祐介, 片桐崇史. Elucidation of background enhancement mechanism in wide-field Raman measurement. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2024. 85th
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Patents (7)：
Lectures and oral presentations (80)：
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Handheld NIR Raman system for intraoperative use in gastroenterological surgery
(Photonics West 2026 BiOS 2026)
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光情報工学が拓く次世代病理組織診断支援システム開発
(第64回 日本臨床細胞学会 秋季大会 2025)
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Optical information engineering for future healthcare and medicine: Applications of Raman spectroscopy for pathological diagnosis
(2025)
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Applications of spontaneous Raman spectroscopy for minimally invasive therapy and predisease detection
(SCIX2025 2025)
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Clinical applications of Raman spectroscopy for minimally invasive surgery and rapid diagnosis
(PHOTONICS & OPTICS international congress 2025 2025)
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Education (4)：
- 2007 - 2010 Aoyama Gakuin University Graduate School of Science and Engineering Ph.D. student
- 2005 - 2007 Aoyama Gakuin University Graduate School of Science and Engineering Master course student
- 2001 - 2005 Aoyama Gakuin University College of Science Engineering Department of Chemistry and Biological Science
- 1998 - 2001 桐光学園高等学校
Professional career (1)：
Work history (15)：
- 2025/04 - 現在 富山大学大学院医薬理工学環メディカルデザインプログラム長
- 2024/08 - 現在 University of Toyama Faculty of Engineering Specially Appointed Professor
- 2022/04 - 現在 Oita University Faculty of Medicine
- 2022/04 - 現在 Oita University Faculty of Medicine
- 2018/07 - 現在 Oita University Department of gastroenterology Faculty of Medicine
- 2018/02 - 現在 The University of Tokyo University of Tokyo Hospital
- 2020/01 - 2024/07 University of Toyama Faculty of Engineering Associate professor
- 2018/02 - 2019/12 Tohoku University Graduate School of Biomedical Engineering
- 2017/04 - 2018/01 Ehime University Ehime University Hospital Assistant Professor
- 2012/04 - 2017/03 Ehime University Graduate School of Medicine Assistant Professor
- 2011/11 - 2012/03 Ehime University Ehime University Hospital Assistant Professor
- 2010/04 - 2011/10 National Institutes of Natural Sciences National Institute for Basic Biology Postdoctral Fellow
- 2007/10 - 2010/03 JSPS Research Fellowship for Young Scientists
- 2004/05 - 2010/03 RIKEN
- 2008/08 - 2008/10 University of Louisville School of Medicine Research School
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Committee career (3)：
- 2025/04 - 現在 日本レーザー医学会西日本支部 評議員
- 2023/04 - 現在 一般社団法人 レーザー学会 レーザー学会学術講演会第44回年次大会 レーザー医学・生物学プログラム委員
- 2018/06 - 2021/03 一般社団法人レーザー学会 レーザーバイオ医療技術専門委員会
Awards (4)：
- 2016/11 - 日本分子生物学会 第39回年会優秀ポスター賞 変形性関節症モデルマウスを用いた関節軟骨の変性過程のラマンスペクトル解析
- 2015/06 - 日本がん分子標的治療学会 第19回学術集会優秀ポスター賞 がん診断のためのラマン分光・イメージング技術の開発
- 2012/05 - レーザー学会 学術講演会第32回年次大会優秀論文発表賞 がん研究・再生医療研究のための浮遊細胞ラマン計測技術の開発
- 2007/03 - 青山学院大学 青山学院スカラーシップ薦田先端学術賞
Association Membership(s) (7)：
日本コンピュータ外科学会
, 日本レーザー医学会
, 日本がん転移学会
, 日本バイオインフォマティックス学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, SPIE
, THE LASER SOCIETY OF JAPAN
