Rchr
J-GLOBAL ID：201601016958271260
Update date: Sep. 13, 2024
Nobuyoshi Akimitsu
アキミツ ノブヨシ | Nobuyoshi Akimitsu
Affiliation and department：
Job title：
教授
Homepage URL (1)：
https://www.ric.u-tokyo.ac.jp/akimitsu/
Research field (5)：
Radiology
, Environmental effects of chemicals
, Environmental effects of radiation
, Pharmaceuticals - health and biochemistry
, Molecular biology
Research keywords (6)：
Nucleic acid therapy
, radiopharmaceutical agent
, がん
, 放射線生物学
, 生化学
, 分子生物学
Research theme for competitive and other funds (38)：
- 2023 - 2028 Dynamic reproductive lifespan: Life-long changes and fluctuations in germ cell function and risk for next generation
- 2023 - 2026 α線放出核種と抗体ドラッグデリバリーシステムによる新規放射性医薬品の開発
- 2021 - 2025 Study of novel stress response mechanism in human cells
- 2021 - 2024 Construction of Multiple Sample Analysis System Using FRET System and Search for Inhibitors of Virus Polymerization Proteins
- 2021 - 2023 Nuclear RNA body-mediated chromatin regulation in heat shock
- 2020 - 2023 眼圧と房水による眼球組織応答と緑内障ー眼圧制御機構とバイオマーカーの探索
- 2020 - 2022 study of post-transcriptional gene regulation in hypoxic cells from the view of metabolic adaptation
- 2019 - 2022 Long noncoding RNAs involved in the pathogenesis of infectious uveitis
- 2019 - 2022 Analysis of the treatment for gastric cancer peritoneal metastasis using hyper-selective short lived alpha-emitting radio isotope
- 2018 - 2022 Development of strategy to design anticancer drug based on ceRNA network
- 2018 - 2022 自然免疫応答を制御する長鎖非コードRNAに関する研究
- 2018 - 2021 RNA metabolism during cellular transition
- 2018 - 2021 Functional analysis of lncRNAs regulating immune response
- 2017 - 2021 Development of new technologies for liver surgery by using fluorescent imaging
- 2017 - 2020 Elucidation of functional role of long non-coding RNA in the invasion of hepatocellular carcinoma cells
- 2017 - 2019 Systematic discovery of short peptide coding ORFs in the human genomes
- 2015 - 2018 Analysis of nuclear non-coding RNA upon bacterial infection
- 2015 - 2018 Study of long noncoding RNAs in immune response
- 2015 - 2018 Mechanism of cluster DNA damage induction and its repair processes in vivo
- 2015 - 2017 核内長鎖ノンコーディングRNAによる転写サイクル制御
- 2015 - 2017 Development of cell sensor by using RNA binding protein
- 2014 - 2017 Search for antiviral molecules from coral reef organisms
- 2015 - 2016 Evaluation of radiation effect based on point mutation of BRAF gene
- 2011 - 2016 Establishment of new diagnostic imaging system for hepatocellular carcinoma and its application to cancer therapy
- 2012 - 2015 Control of Biological Effect by Altered ATP induced with Synchrotron Soft X-rays
- 2012 - 2014 RNA分解を介した核局在型高分子非コードRNA作用マシナリーの制御機構の解明
- 2012 - 2014 Study of Biological Effect induced by Radiation Damage of non-DNA Molecules
- 2011 - 2012 Transcriptional regulation of nuclear long noncoding RNA in mammalian cells
- 2011 - 2012 Body-brain holistic biology on the gravity health science platform
- 2010 - 2011 哺乳動物細胞の核内非コードRNA分解経路に関する研究
- 2010 - 2010 ノンコーディングRNAに着目した疾患マーカーの新規発見手法の開発
- 2008 - 2009 Analysis of translational inhibition by basic amino acid repeat
- 2006 - 2007 終止コドンを欠失したmRNAの特異的分解に関与するヒト遺伝子群の網羅的検索と解析
- 2002 - 2003 Functions of transcription elongation factor S-II for cell stress response and development
- 2002 - 2003 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学
- 2002 - 2002 マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性
- 2001 - 2001 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学
- 2000 - 2001 Functional analysis of a role of prolylendopeptidase in brain by constructing gene targeting mice
Show all
Papers (100)：
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Ryota Imura, Jaewoong Jang, Atsuko Nakanishi Ozeki, Hiroyuki Takahashi, Hiroyuki Ida, Youichiro Wada, Yoshitaka Kumakura, Nobuyoshi Akimitsu. Click Chemistry Enables [89Zr]Zr-DOTA Radioimmunoconjugation for Theranostic 89Zr-immunoPET. Bioconjugate chemistry. 2024
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Kenzui Taniue, Takeaki Oda, Tomoatsu Hayashi, Yuki Kamoshida, Yasuko Takeda, Anzu Sugawara, Yuki Shimoura, Lumi Negishi, Takeshi Nagashima, Mariko Okada-Hatakeyama, et al. LncRNA ZNNT1 induces p53 degradation by interfering with the interaction between p53 and the SART3-USP15 complex. PNAS Nexus. 2023. 2. 7. pgad220
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Yasuyuki Shima, Shota Sasagawa, Nakao Ota, Rieko Oyama, Minoru Tanaka, Mie Kubota-Sakashita, Hirochika Kawakami, Mika Kobayashi, Naoko Takubo, Atsuko Nakanishi Ozeki, et al. Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Science translational medicine. 2023. 15. 700. eabq7721
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Tatsuaki Kurosaki, Shuhei Mitsutomi, Alexander Hewko, Nobuyoshi Akimitsu, Lynne E Maquat. Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells. Molecular cell. 2022. 82. 23. 4564-4581
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小畑 結衣, 木名瀬 暁理, 伊東 祐真, 秋光 信佳, 横谷 明徳. ヒト細胞中に導入された線形プラスミドDNAは遺伝子発現をするのか?(Does linear plasmid DNA express genes in it after transfected into human cells). 日本放射線影響学会大会講演要旨集. 2022. 65回. 126-126
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MISC (91)：
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Imura Ryota, Imura Ryota, Imura Ryota, Ozeki Atsuko Nakanishi, Shida Nanako, Kobayashi Mika, Ida Hiroyuki, Wada Youichiro, Wada Youichiro, Akimitsu Nobuyoshi, et al. Radiolabeling of PSMA-617 with 89Zr: A novel use of DMSO to improve radiochemical yield and preliminary small-animal PET results. Nuclear Medicine and Biology. 2022. 106-107. 21-28
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小畑 結衣, 平嵜 敬志朗, 秋光 信佳, 鈴木 雅雄, 横谷 明徳. 放射線損傷DNAの細胞内修復ダイナミクス可視化のための新たなベクターDNA系の開発(Development of a vector DNA system for visualization of intracellular repair dynamics of DNA damage by ionizing radiation). 日本放射線影響学会大会講演要旨集. 2020. 63回. 59-59
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小畑 結衣, 平嵜 敬志朗, 秋光 信佳, 鈴木 雅雄, 横谷 明徳. 放射線損傷DNAの細胞内修復ダイナミクス可視化のための新たなベクターDNA系の開発(Development of a vector DNA system for visualization of intracellular repair dynamics of DNA damage by ionizing radiation). 日本放射線影響学会大会講演要旨集. 2020. 63回. 68-68
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秋光 信佳, 小野口 玲菜, 川村 猛, Diederichs Sven, 鈴木 穣. ノンコーティングRNAによるエピジェネティクスの制御 ストレス応答における核内長鎖ノンコーディングRNAの働き(Epigenetic regulation by non-coding RNAs Functions of nuclear long noncoding RNAs in stress responses). 日本癌学会総会記事. 2019. 78回. IS12-4
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秋光 信佳. 中分子創薬への放射線活用. 日本薬学会年会要旨集. 2019. 139年会. 1. 343-343
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Patents (6)：
Books (5)：
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未来へ繋ぐ災害対策 : 科学と政治と社会の協働のために
有斐閣 2022 ISBN:9784641174801
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福島復興知学講義
東京大学出版会 2021 ISBN:9784130520300
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遺伝子発現制御機構 : クロマチン, 転写制御, エピジェネティクス
東京化学同人 2017 ISBN:9784807909179
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細胞の酸化ストレス応答並びに個体発生における転写伸長因子S-IIの機能
関水和久 2004
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遺伝子ノックアウトマウス作製によるプロリルエンドぺプチターゼの脳における機能解析
秋光信佳 2002
Professional career (1)：
Association Membership(s) (6)：
THE JAPANESE RADIATION RESEARCH SOCIETY
, THE RNA SOCIETY OF JAPAN
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, RNA society
, 日本癌学会
