Art

J-GLOBAL ID：201602218539067045   Reference number：16A0800425

Intracellular Metabolism of α,β-Unsaturated Carbonyl Compounds, Acrolein, Crotonaldehyde and Methyl Vinyl Ketone, Active Toxicants in Cigarette Smoke: Participation of Glutathione Conjugation Ability and Aldehyde-Ketone Sensitive Reductase Activity

タバコ煙内の活性中毒物質であるα,β-不飽和カルボニル化合物であるアクロレインとクロトンアルデヒドとメチルビニルケトンの細胞内代謝:グルタチオン抱合能およびアルデヒド-ケトン感受性レダクターゼ活性の関与

Author (11)： Horiyama Shizuyo (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Hatai Mayuko (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Takahashi Yuta (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Date Sachiko (Riken Quantitative Biology Center, OLABB, Osaka University) ,  Masujima Tsutomu (Riken Quantitative Biology Center, OLABB, Osaka University) ,  Honda Chie (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Ichikawa Atsushi (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Yoshikawa Noriko (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nakamura Kazuki (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kunitomo Masaru (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Takayama Mitsuo (International Graduate School of Arts and Sciences, Yokohama City University)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 64  Issue： 6  Page： 585-593(J-STAGE)  Publication year： 2016 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *aerosol (suspended solids) ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (10)： cigarette smoke extract (CSE) ,  glutathione (GSH) ,  αβ-unsaturated aldehyde ,  αβ-unsaturated ketone ,  LC/MS ,  cigarette smoke extract (CSE) ,  glutathione (GSH) ,  αβ-unsaturated aldehyde ,  αβ-unsaturated ketone ,  LC/MS

JST classification (2)： Tobacco(=cigarette)  (FJ07000D) ,  Metabolism and biotransformasion of xenobiotics  (EJ02037P)

Substance index (4)： Acrolein ,  Crotonaldehyde ,  Methyl vinyl ketone ,  Glutathione

Reference (28)：

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• 5) Aoshiba K., Nagai A., Tob. Induc. Dis, 1, 219-226 (2003).

Terms in the title (15)： タバコ煙 ,  活性 ,  中毒 ,  物質 ,  不飽和 ,  カルボニル化合物 ,  アクロレイン ,  クロトンアルデヒド ,  メチルビニルケトン ,  代謝 ,  グルタチオン抱合 ,  アルデヒド ,  ケトン ,  感受性 ,  レダクターゼ