Art

J-GLOBAL ID：201602231497953358   Reference number：16A0658864

アルツハイマー病におけるPS2V研究の新展開

Author (5)： SHIBA YUKO (中京学院大 看護) ,  MORIKAWA TOMOMI (中京学院大 看護) ,  MANABE TAKAYUKI (中京学院大 看護) ,  MANABE TAKAYUKI (大阪大 大学院連合小児発達学研究科) ,  MANABE TAKAYUKI (藤田保健衛生大 総合医科研)
Material： 脳21  (Brain 21)
Volume： 19  Issue： 3  Page： 302-305  Publication year： Jul. 20, 2016 
JST Material Number： L3821A  ISSN： 1344-0128  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Alzheimer disease ,...
Semi thesaurus term： *PS2V ,...

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JST classification (3)： Nervous system diseases  (GN03000O) ,  Biological function  (EB03040U) ,  Gene expression  (EC02040Q)

Reference (14)：

• Morikawa T and Manabe T : Aberrant regulation of alternative splicing in schizophrenia. Neurochem Int 57 : 691-704, 2010.
• Sato N, et al : A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue. J Neurochem 72 : 2498-2505, 1999.
• Sato N, et al : Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. J Biol Chem 276 : 2108-2114, 2001.
• Manabe T, et al : The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients. Neurosci Lett 328: 198-200, 2002.
• Smith MJ, et al : Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex. Brain Res Mol Brain Res 127: 128-135, 2004.

Terms in the title (3)： アルツハイマー病 ,  研究 ,  展開