Art

J-GLOBAL ID：201602239583141984   Reference number：16A0486773

Role of metabolic signaling in the regulation of cognitive functions

糖代謝シグナルを介した認知機能制御機構

Author (6)： TADA HIROBUMI (国立療養所中部病院 長寿医療研セ) ,  TOKUNAGA AKINORI (国立療養所中部病院 長寿医療研セ) ,  TANOKASHIRA DAISUKE (国立療養所中部病院 長寿医療研セ) ,  KURATA EIKO (宮崎大 医 内科 神経呼吸内分泌代謝学分野) ,  TAGUCHI AKIKO (国立療養所中部病院 長寿医療研セ) ,  TAGUCHI AKIKO (宮崎大 医 内科 神経呼吸内分泌代謝学分野)
Material： 基礎老化研究  (Biomedical Gerontology)
Volume： 40  Issue： 2  Page： 9-14  Publication year： May. 27, 2016 
JST Material Number： Y0748A  ISSN： 0912-8921  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *carbohydrate metabolism ,...
Semi thesaurus term： *cellular signal transduction ,...

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JST classification (4)： Basic neurology  (GN01020W) ,  Metabolism and nutrition of sugar(=glucide)  (EJ02035H) ,  Central nervous system  (EJ12030F) ,  Cell physiology in general  (EF02010S)

Reference (25)：

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• Schrijvers EM, Witteman JC, Sijbrands EJ, et al. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 75:1982-1987, 2010.
• Ohara T, Doi Y, Ninomiya T, et al. Glucose tolerance status and risk of dementia in the community : the Hisayama study. Neurology 77 : 1126-1134, 2011.
• Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122 : 1316-1338, 2012.
• Kasuga M, Zick Y, Blithe DL, et al. Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature 298:667-669, 1982.

Terms in the title (3)： 糖代謝 ,  シグナル ,  認知機能