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J-GLOBAL ID：201602242478222626   Reference number：16A0906094

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

siRNAデリバリーに対するsiRNA負荷小サイズ脂質ナノ粒子の物理化学的性質および活性の解明

Author (10)： Sato Yusuke (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Note Yusuke (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Maeki Masatoshi (Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan) ,  Kaji Noritada (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Kaji Noritada (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Baba Yoshinobu (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Baba Yoshinobu (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Tokeshi Manabu (Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan) ,  Tokeshi Manabu (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Harashima Hideyoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan)
Material： Journal of Controlled Release  (J Control Release)
Volume： 229  Page： 48-57  Publication year： May. 10, 2016 
JST Material Number： C0308D  ISSN： 0168-3659  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *gene introduction ,...
Semi thesaurus term： *siRNA delivery ,...

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Author keywords (6)： Small-sized lipid nanoparticles ,  siRNA delivery ,  Microfluidic device ,  Protein adsorption ,  Stability ,  Endosomal escape

JST classification (3)： Gene manipulation  (EC02050B) ,  Medical materials  (GA05040H) ,  Experimental treatment for tumors  (GE02040Y)

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Terms in the title (6)： siRNAデリバリー ,  siRNA ,  小サイズ ,  脂質ナノ粒子 ,  物理化学的性質 ,  活性