Art

J-GLOBAL ID：201602247569797160   Reference number：16A0643998

Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells

Srcは膵臓β細胞においてグルコキナーゼの細胞内局在に影響することでインスリン分泌とグルコース代謝を調節する

Author (14)： Sato Hiroki (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Nagashima Kazuaki (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Ogura Masahito (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sato Yuichi (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tahara Yumiko (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Ogura Kasane (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Yamano Gen (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sugizaki Kazu (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Fujita Naotaka (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tatsuoka Hisato (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Usui Ryota (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Mukai Eri (Department of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Fujimoto Shimpei (Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan) ,  Inagaki Nobuya (Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
Material： Journal of Diabetes Investigation (Web)  (JDI (Web))
Volume： 7  Issue： 2  Page： 171-178  Publication year： 2016 
JST Material Number： U0507A  ISSN： 2040-1124  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： endocrine cell ,...
Semi thesaurus term： pancreatic beta-cell ,...

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Author keywords (3)： Glucokinase ,  Insulin secretion ,  Src

JST classification (1)： Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (43)：

• Maechler P, Wollheim CB. Mitochondrial function in normal and diabetic β-cells. Nature 2001; 414: 807-812.
• Montane J, Cadavez L, Novials A. Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. Diabetes Metab Syndr Obes 2014; 7: 25-34.
• Fujimoto S, Mukai E, Inagaki N. Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic β cells. Prog Biophys Mol Biol 2011; 107: 304-310.
• Kominato R, Fujimoto S, Mukai E, et al. Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain treated rat pancreatic islets. Diabetologia 2008; 51: 1226-1235.
• Mukai E, Fujimoto S, Sato H, et al. Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. Diabetes 2011; 60: 218-226.

Terms in the title (7)： SRC ,  膵臓β細胞 ,  グルコキナーゼ ,  細胞内局在 ,  インスリン分泌 ,  グルコース代謝 ,  調節