Art

J-GLOBAL ID：201602273957270689   Reference number：16A1007923

Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer’s disease

in vitroアルツハイマー病モデルにおける治療的介入のためのトロロックス結合アミロイド-β C末端ペプチドの設計,合成並びに評価

Author (14)： Arai Takuya (Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Arai Takuya (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Ohno Akiko (Division of Organic Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Kazunori Mori (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Kakizawa Taeko (Division of Organic Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Kuwata Hiroshi (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Ozawa Toshihiko (Division of Oxidative Stress Research, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida-shi, Tokyo 194-8543, Japan) ,  Shibanuma Motoko (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Hara Shuntaro (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Ishida Seiichi (Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Kurihara Masaaki (Division of Organic Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan) ,  Miyata Naoki (Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Nakagawa Hidehiko (Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan) ,  Fukuhara Kiyoshi (School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 18  Page： 4138-4143  Publication year： Sep. 15, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *amyloid beta-protein ,  peptide ,  molecular targeting drug ,  peptide synthesis ,  drug design ,  chemical synthesis ,  antioxidant ,  molecular compound ,  chain length effect ,  molecular chain ,  structure-activity relationship ,  aggregation ,  cultured cell ,  in vitro experiment ,  oxidative stress ,  *anti-Alzheimer's disease drug ,  *fat-soluble vitamin ,  carboxylic acid ,  phenolic compound ,  oxygen heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： *A .BETA. peptide ,  peptide drugs ,  drug synthesis ,  A beta 1-42 ,  protein aggregation ,  SH-SY5Y cell

Author keywords (7)： Alzheimer’s disease ,  Amyloid-β ,  C-terminal motif ,  Trolox ,  Aggregation inhibitor ,  Antioxidative activity ,  Cell protection

JST classification (2)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Vitamin E  (EB07060S)

Substance index (1)： Trolox

Terms in the title (9)： アルツハイマー病 ,  モデル ,  治療 ,  トロロックス ,  アミロイド ,  C末端 ,  ペプチド ,  設計 ,  評価