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J-GLOBAL ID:201602288658486131   Reference number:16A1134129

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

メトトレキサートは破骨細胞前駆体へのRANKL誘導カルシウム流入の低下により破骨細胞形成を阻害する
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Material:
Volume: 34  Issue:Page: 526-531  Publication year: 2016 
JST Material Number: L0163A  ISSN: 0914-8779  Document type: Article
Article type: 原著論文  Country of issue: Germany, Federal Republic of (DEU)  Language: ENGLISH (EN)
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Basic medicine on musculoskeletal system  ,  Basic research of immunotherapeutic agents and blood preparations 
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Reference (26):
  • Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38:4-9
  • Jaffe N, Paed D, Farber S, Traggis D, Geiser C, Kim BS, Das L, Frauenberger G, Djerassi I, Cassady JR (1973) Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy. Cancer 31:1367-1373
  • Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41:36-51
  • Cope AP (2008) T cells in rheumatoid arthritis. Arthritis Res Ther 10:1
  • Kremer JM, Lee JK (1986) The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum 29:822-831
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