Art

J-GLOBAL ID：201602288658486131   Reference number：16A1134129

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

メトトレキサートは破骨細胞前駆体へのRANKL誘導カルシウム流入の低下により破骨細胞形成を阻害する

Author (19)： Kanagawa Hiroya (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Masuyama Ritsuko (Department of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan) ,  Morita Mayu (Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Sato Yuiko (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Sato Yuiko (Department of Musculoskeletal Reconstruction and Regeneration Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Niki Yasuo (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Kobayashi Tami (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Katsuyama Eri (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Fujie Atsuhiro (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Hao Wu (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Tando Toshimi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Watanabe Ryuichi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Kana (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Morioka Hideo (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Matsumoto Morio (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Toyama Yoshiaki (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Saya Hideyuki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Takeshi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan) ,  Miyamoto Takeshi (Department of Integrated Bone Metabolism and Immunology, Keio University School of Medicine, Tokyo, Japan)
Material： Journal of Bone and Mineral Metabolism  (JBMM)
Volume： 34  Issue： 5  Page： 526-531  Publication year： 2016 
JST Material Number： L0163A  ISSN： 0914-8779  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： drug screening ,...

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Author keywords (4)： Methotrexate ,  Osteoclast ,  Differentiation ,  Calcium influx

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Methotrexate

Reference (26)：

• Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38:4-9
• Jaffe N, Paed D, Farber S, Traggis D, Geiser C, Kim BS, Das L, Frauenberger G, Djerassi I, Cassady JR (1973) Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy. Cancer 31:1367-1373
• Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41:36-51
• Cope AP (2008) T cells in rheumatoid arthritis. Arthritis Res Ther 10:1
• Kremer JM, Lee JK (1986) The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum 29:822-831

Terms in the title (8)： メトトレキサート ,  破骨細胞 ,  前駆体 ,  RANKL ,  誘導 ,  カルシウム流入 ,  破骨細胞形成 ,  阻害