Art

J-GLOBAL ID：201702212524559732   Reference number：17A1295798

Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes

ラット胸腺細胞における化学アレルゲンである4,4′-メチレンジフェニルジイソシアナートの細胞毒性に関するサイトメトリー分析

Author (6)： Oyama Keisuke (Tokushima Prefectural Central Hospital) ,  Oyama Keisuke (Present address: Osaka University Hospital) ,  Miyoshi Norikazu (Faculty of Integrated Arts and Sciences, Tokushima University) ,  Miyoshi Norikazu (Faculty of Science and Technology, Tokushima University) ,  Oyama Yasuo (Faculty of Integrated Arts and Sciences, Tokushima University) ,  Oyama Yasuo (Faculty of Bioscience and Bioindustry, Tokushima University)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 4  Issue： 4  Page： 173-178(J-STAGE)  Publication year： 2017 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： In vitro study ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A1295798&from=J-GLOBAL&jstjournalNo=U0596A") }}

Author keywords (4)： 44′-Methylenediphenyl diisocyanate ,  Cytotoxicity ,  Lymphocytes ,  Flow-cytometer

JST classification (3)： Inorganic acid esters of aromatic monocyclic alcohols,phenols and thiols  (CF05120F) ,  Toxicity of organic compounds  (GZ02030Y) ,  Analysis of drugs  (GV01040Q)

Substance index (5)： A-23187 ,  Fluorescein isothiocyanate ,  Fluo 3 ,  Glutathione ,  MDI

Reference (17)：

• Chikahisa, L., Oyama, Y., Okazaki, E. and Noda, K. (1996): Fluorescent estimation of H₂O₂-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes. Jpn. J. Pharmacol., 71, 299-305.
• Gries, W. and Leng, G. (2013): Analytical determination of specific 4,4′-methylene diphenyl diisocyanate hemoglobin adducts in human blood. Anal. Bioanal. Chem., 405, 7205-7213.
• Imai, H., Kita, F., Ikesugi, S., Abe, M., Sogabe, S., Nishimura-Danjobara, Y., Miura, H. and Oyama, Y. (2017): Cetylpyridinium chloride at sublethal levels increases the susceptibility of rat thymic lymphocytes to oxidative stress. Chemosphere, 170, 118-123.
• Ishidate, M. (1988): Data book of chromosomal aberration test in vitro. Elsevier Publishing Company (Amsterdam).
• Kamae, R., Nojima, S., Akiyoshi, K., Setsu, S., Honda, S., Masuda, T. and Oyama, Y. (2017): Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes. Food Chem. Toxicol., 102, 39-45.

Terms in the title (6)： ラット ,  胸腺細胞 ,  化学 ,  アレルゲン ,  細胞毒性 ,  分析