Art

J-GLOBAL ID：201702212524559732   Reference number：17A1295798

Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes

ラット胸腺細胞における化学アレルゲンである4,4′-メチレンジフェニルジイソシアナートの細胞毒性に関するサイトメトリー分析

Author (6)： Oyama Keisuke (Tokushima Prefectural Central Hospital) ,  Oyama Keisuke (Present address: Osaka University Hospital) ,  Miyoshi Norikazu (Faculty of Integrated Arts and Sciences, Tokushima University) ,  Miyoshi Norikazu (Faculty of Science and Technology, Tokushima University) ,  Oyama Yasuo (Faculty of Integrated Arts and Sciences, Tokushima University) ,  Oyama Yasuo (Faculty of Bioscience and Bioindustry, Tokushima University)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 4  Issue： 4  Page： 173-178(J-STAGE)  Publication year： 2017 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： In vitro study ,...

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Author keywords (4)： 44′-Methylenediphenyl diisocyanate ,  Cytotoxicity ,  Lymphocytes ,  Flow-cytometer

JST classification (3)： Inorganic acid esters of aromatic monocyclic alcohols,phenols and thiols  (CF05120F) ,  Toxicity of organic compounds  (GZ02030Y) ,  Analysis of drugs  (GV01040Q)

Substance index (5)： A-23187 ,  Fluorescein isothiocyanate ,  Fluo 3 ,  Glutathione ,  MDI

Reference (17)：

• Chikahisa, L., Oyama, Y., Okazaki, E. and Noda, K. (1996): Fluorescent estimation of H₂O₂-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes. Jpn. J. Pharmacol., 71, 299-305.
• Gries, W. and Leng, G. (2013): Analytical determination of specific 4,4′-methylene diphenyl diisocyanate hemoglobin adducts in human blood. Anal. Bioanal. Chem., 405, 7205-7213.
• Imai, H., Kita, F., Ikesugi, S., Abe, M., Sogabe, S., Nishimura-Danjobara, Y., Miura, H. and Oyama, Y. (2017): Cetylpyridinium chloride at sublethal levels increases the susceptibility of rat thymic lymphocytes to oxidative stress. Chemosphere, 170, 118-123.
• Ishidate, M. (1988): Data book of chromosomal aberration test in vitro. Elsevier Publishing Company (Amsterdam).
• Kamae, R., Nojima, S., Akiyoshi, K., Setsu, S., Honda, S., Masuda, T. and Oyama, Y. (2017): Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes. Food Chem. Toxicol., 102, 39-45.

Terms in the title (6)： ラット ,  胸腺細胞 ,  化学 ,  アレルゲン ,  細胞毒性 ,  分析