Art

J-GLOBAL ID：201702228748876021   Reference number：17A0509550

Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells

HEK293細胞で安定に発現するP123S変異体ペンドリンの局在を救済する新しい分子シャペロンとしての(2-アミノフェニル)メタノールの発見

Author (6)： Nabeyama Wataru (Department of Life Science, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan) ,  Ishihara Kenji (Laboratory of Medical Science, Course for School Nurse Teacher, Faculty of Education, Ibaraki University, Mito 310-8512, Japan) ,  Ban Hyun Seung (Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea) ,  Wada Hiroshi (Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan) ,  Wada Hiroshi (Department of Intelligent Information Systems, Tohoku Bunka Gakuen University, Sendai 981-8511, Japan) ,  Nakamura Hiroyuki (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 25  Issue： 9  Page： 2601-2608  Publication year： May. 01, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Ion Channels ,  carboxylate (ester) ,  carboxylate (salt) ,  hydroxy acid ,  phenolic compound ,  aromatic carboxylic acid ,  hereditary disease ,  Goiter ,  chromosome disorder ,  concentration dependence ,  gene ,  Mutation ,  sensorineural hearing loss ,  HEK293 cell ,  subcellular distribution ,  radiant intensity ,  cytotoxicity ,  mutant ,  time dependence ,  confocal laser scanning microscope ,  SLC26A4 gene ,  *pendrin ,  fluorescence intensity ,  intracellular localization ,  Salicylates ,  *Ion Transport ,  *transportation ,  *Biological Transport ,  *transmembrane protein ,  *ion transport(in vivo)
Semi thesaurus term： Pendred's syndrome ,  Salicylates

Author keywords (7)： Hearing loss ,  Pendrin ,  P123S mutant ,  Misfolding ,  Molecular chaperone ,  Localization ,  Morphological analysis

JST classification (2)： Biological function  (EB03040U) ,  Nitrogen heterocycles in general  (CF07040G)

Substance index (1)： 2-Aminobenzyl alcohol

Terms in the title (7)： HEK293細胞 ,  発現 ,  変異体 ,  ペンドリン ,  分子シャペロン ,  メタノール ,  発見