Art

J-GLOBAL ID：201702234360228485   Reference number：17A1261547

Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis

Bacillus subtilisにおけるワルジオマイシンの作用に対して不活性なWalKのHボックス領域突然変異体の特性化

Author (8)： Kato Akinori (Department of Advanced Bioscience, Graduate School of Agriculture, Kindai University) ,  Ueda Shuhei (Department of Advanced Bioscience, Graduate School of Agriculture, Kindai University) ,  Oshima Taku (Graduate School of Biological Sciences, Nara Institute of Science and Technology) ,  Inukai Yoichi (Department of Advanced Bioscience, Graduate School of Agriculture, Kindai University) ,  Okajima Toshihide (Institute of Scientific and Industrial Research, Osaka University) ,  Igarashi Masayuki (Institute of Microbial Chemistry, Tokyo) ,  Eguchi Yoko (Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University) ,  Utsumi Ryutaro (Department of Advanced Bioscience, Graduate School of Agriculture, Kindai University)
Material： Journal of General and Applied Microbiology  (J Gen Appl Microbiol)
Volume： 63  Issue： 4  Page： 212-221(J-STAGE)  Publication year： 2017 
JST Material Number： G0463A  ISSN： 0022-1260  CODEN： JGAMA9  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Bacillus subtilis ,...
Semi thesaurus term： CitS ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A1261547&from=J-GLOBAL&jstjournalNo=G0463A") }}

Author keywords (8)： Antibiotics ,  Bacillus subtilis (B. subtilis) ,  H-box region ,  Histidine kinase (HK) ,  inhibitor ,  two-component system (TCS) ,  Waldiomycin ,  WalK/WalR

JST classification (2)： Enzyme in general  (EB09010D) ,  Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (1)： Waldiomycin

Reference (19)：

• Anagnostopoulos, C. and Spizizen, J. (1961) Requirements for transformation in Bacillus subtilis. J. Bacteriol., 81, 741-746.
• Bem, A. E., Velikova, N., Pellicer, M. T., Baarlen, P., Marina, A. et al. (2015) Bacterial histidine kinases as novel antibacterial drug targets. ACS Chem. Biol., 10, 213-224.
• Dubrac, S., Bisicchia, P., Devine, K. M., and Msadek, T. (2008) A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway. Mol. Microbiol., 70, 1307-1322.
• Fabret, C. and Hoch, J. A. (1998) A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy. J. Bacteriol., 180, 6375-6383.
• Fakhruzzaman, M., Inukai, Y., Yanagida, Y., Kino, H., Igarashi, M. et al. (2015) Study on in vivo effects of bacterial histidine kinase inhibitor, Waldiomycin, in Bacillus subtilis and Staphylococcus aureus. J. Gen. Appl. Microbiol., 61, 177-184.

Terms in the title (6)： Bacillus ,  ワルジオマイシン ,  不活性 ,  ボックス ,  突然変異体 ,  特性化