Rchr
J-GLOBAL ID：200901066932650516
Update date: Sep. 28, 2024
Okajima Toshihide
オカジマ トシヒデ | Okajima Toshihide
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Structural biochemistry
, Applied biochemistry
, Functional biochemistry
Research keywords (5)：
創薬
, 酵素反応機構
, 構造生物学
, 酵素化学
, Enzyme chemistry
Research theme for competitive and other funds (21)：
- 2022 - 2025 Elucidation of the biogenesis mechanism of amine dehydrogenase by development of a low-cytotoxicity genome editing technique for bacteria
- 2022 - 2025 Mechanistic analysis and its optimization of bioactive cyclic peptides constructed by a radical cross-linking enzyme
- 2020 - 2023 Development for quantum-theoretical approach by observing hydrogen atom positions in drug target proteins
- 2019 - 2022 Elucidation of quinone cofactor biogenesis in copper amine oxidase on the basis of proton structures and flexibility analysis
- 2016 - 2020 Elucidation of enzyme catalytic mechanism regulating transition state by linking conformational change and fluctuations of the active site
- 2016 - 2019 Mechanism of multi-step posttranslational modification involved in biogenesis of amine dehydrogenase and its application to development of bioactive polycyclic peptides
- 2015 - 2018 Reaction mechanism of novel tryptophan-hydroxylating enzyme involving in quinone cofactor biogenesis
- 2012 - 2015 Mechanism of FeS cluster-binding crosslink enzyme and production of novel cyclic peptide
- 2009 - 2011 Molecular mechanism of persisting activation of glutamate-gated chloride channels by macrolide compounds
- 2006 - 2009 Mechanism of Biogenesis and Catalytic Function of Peptidyl Built-in Quinone Cofactors
- 2006 - 2008 Structural and kinetic studies for the refined reaction mechanism in built-in-cofactor dependent quinone enzymes mediating proton and electron transfers
- 2002 - 2004 Mechanism of biogenesis for built-in type quinone cofactor and application for composite-type catalytic antibody
- 2001 - 2003 Molecular Design of Composite Biocatalysts Containing Built-in Quinone Cofactor and Metals
- 2002 - 2002 触媒抗体による新しい感染制御手法の開発
- 2000 - 2002 Structure, Catalytic Function and Biogenesis Mechanism of Novel Built-in Quinone Cofactors
- 2000 - ビルトイン型キノン補酵素の生合成機構
- 1996 - 1996 ヌクレオシド一リン酸キナーゼ基質認識機構の解析
- 1995 - 1995 ヌクレオシドーリン酸キナーゼ基質認識機構の解析
- 1994 - 1994 ヌクレオシド一リン酸キナーゼ基質認識機構の解析
- 銅/トパキノン含有アミン酸化酵素の触媒機構と構造
- Catalytic mechanism and structure of copper/topaquinone-containing amine oxidase
Show all
Papers (105)：
-
Ryo Ito, Masaki Kamiya, Koichi Takayama, Sumito Mori, Rei Matsumoto, Mayuka Takebayashi, Hisanori Ojima, Shota Fujimura, Haruki Yamamoto, Masayuki Ohno, et al. Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquito Anopheles gambiae. Open Biology. 2024. 14. 7
-
Teruhiko Ishikawa, Yoko Eguchi, Masayuki Igarashi, Toshihide Okajima, Kohei Mita, Yuri Yamasaki, Kaho Sumikura, Taisei Okumura, Yuna Tabuchi, Chigusa Hayashi, et al. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. The Journal of Antibiotics. 2024. 77. 8. 522-532
-
Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Naomine Yano, Katsuhiro Kusaka, Yoshiaki Kawano, Mamoru Suzuki, Yasuteru Shigeta, Takato Yano, Motoyasu Adachi, et al. Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase Reveals a Substrate-Assisted Conformational Change of the Peptidyl Quinone Cofactor. ACS Catalysis. 2023. 12403-12413
-
Takeshi Murakawa, Mamoru Suzuki, Kenji Fukui, Tetsuya Masuda, Michihiro Sugahara, Kensuke Tono, Tomoyuki Tanaka, So Iwata, Eriko Nango, Takato Yano, et al. Serial femtosecond X-ray crystallography of an anaerobically formed catalytic intermediate of copper amine oxidase. Acta Crystallographica Section D Structural Biology. 2022. 78. 12. 1428-1438
-
Martina Pasqua, Marco Coluccia, Yoko Eguchi, Toshihide Okajima, Milena Grossi, Gianni Prosseda, Ryutaro Utsumi, Bianca Colonna. Roles of Two-Component Signal Transduction Systems in Shigella Virulence. Biomolecules. 2022. 12. 9. 1321-1321
ｍore...
MISC (94)：
-
斎藤遥, 大原ひかる, 小林勇気, 田中寛, 五十嵐雅之, 内海龍太郎, 岡島俊英, 華岡光正, 華岡光正. Cyanidioschyzon merolaeの光応答転写制御におけるヘムの関与. 日本農芸化学会関東支部講演要旨集(CD-ROM). 2022. 2022
-
村川 武志, 岡島 俊英. 宙に浮く水素イオン?!-大型タンパク質の中性子結晶構造解析で見えた特異な世界-(4月28日、プレス発表). J-PARC News 第181号. 2020. 181. 2-2
-
宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 量子科学技術研究開発機構. 2020
-
銅アミン酸化酵素の中性子結晶構造解析に成功 -宙に浮いているようにみえる水素イオンなど初めて解明. 茨城大学. 2020
-
宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 大阪大学. 2020
ｍore...
Books (4)：
-
Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology
CRC Press, FL, USA 2009
-
酵素ハンドブック第3版
朝倉書店 2008
-
蛋白質科学
化学同人、京都 2006
-
構造生物学 : ヌクレオシド-リン酸キナーゼ
朝倉書店 1997
Education (2)：
- - 1992 Osaka University
- - 1987 Tokyo University of Science Faculty of Science and Technology Applied Biological Science
Professional career (1)：
- (BLANK) (Osaka University)
Work history (5)：
- 2007/04 - 現在 大阪大学産業科学研究所 准教授
- 2002/11 - 2007/03 大阪大学産業科学研究所 助教授
- 2000/04 - 2002/11 Osaka University The Institute of Scientific and Industrial Research
- 1995/04 - 2000/03 Kindai University Faculty of Agriculture
- 1992/04 - 1995/03 Kindai University Faculty of Agriculture
Awards (2)：
- 2021/03 - 公益社団法人日本農芸化学会 第18回農芸化学研究企画賞
- 2017/04 - 長瀬科学技術振興財団 長瀬研究振興賞受賞
Association Membership(s) (4)：
日本蛋白科学会
, Protein Society
, 日本農芸化学会
, 日本生化学会
