Rchr
J-GLOBAL ID：200901066932650516
Update date: Feb. 02, 2024
Okajima Toshihide
オカジマ トシヒデ | Okajima Toshihide
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Structural biochemistry
, Applied biochemistry
, Functional biochemistry
Research keywords (5)：
創薬
, 酵素反応機構
, 構造生物学
, 酵素化学
, Enzyme chemistry
Research theme for competitive and other funds (21)：
- 2022 - 2025 Elucidation of the biogenesis mechanism of amine dehydrogenase by development of a low-cytotoxicity genome editing technique for bacteria
- 2022 - 2025 Mechanistic analysis and its optimization of bioactive cyclic peptides constructed by a radical cross-linking enzyme
- 2020 - 2023 Development for quantum-theoretical approach by observing hydrogen atom positions in drug target proteins
- 2019 - 2022 Elucidation of quinone cofactor biogenesis in copper amine oxidase on the basis of proton structures and flexibility analysis
- 2016 - 2020 Elucidation of enzyme catalytic mechanism regulating transition state by linking conformational change and fluctuations of the active site
- 2016 - 2019 Mechanism of multi-step posttranslational modification involved in biogenesis of amine dehydrogenase and its application to development of bioactive polycyclic peptides
- 2015 - 2018 Reaction mechanism of novel tryptophan-hydroxylating enzyme involving in quinone cofactor biogenesis
- 2012 - 2015 Mechanism of FeS cluster-binding crosslink enzyme and production of novel cyclic peptide
- 2009 - 2011 Molecular mechanism of persisting activation of glutamate-gated chloride channels by macrolide compounds
- 2006 - 2009 Mechanism of Biogenesis and Catalytic Function of Peptidyl Built-in Quinone Cofactors
- 2006 - 2008 Structural and kinetic studies for the refined reaction mechanism in built-in-cofactor dependent quinone enzymes mediating proton and electron transfers
- 2002 - 2004 Mechanism of biogenesis for built-in type quinone cofactor and application for composite-type catalytic antibody
- 2001 - 2003 Molecular Design of Composite Biocatalysts Containing Built-in Quinone Cofactor and Metals
- 2002 - 2002 触媒抗体による新しい感染制御手法の開発
- 2000 - 2002 Structure, Catalytic Function and Biogenesis Mechanism of Novel Built-in Quinone Cofactors
- 2000 - ビルトイン型キノン補酵素の生合成機構
- 1996 - 1996 ヌクレオシド一リン酸キナーゼ基質認識機構の解析
- 1995 - 1995 ヌクレオシドーリン酸キナーゼ基質認識機構の解析
- 1994 - 1994 ヌクレオシド一リン酸キナーゼ基質認識機構の解析
- 銅/トパキノン含有アミン酸化酵素の触媒機構と構造
- Catalytic mechanism and structure of copper/topaquinone-containing amine oxidase
Show all
Papers (103)：
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Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Naomine Yano, Katsuhiro Kusaka, Yoshiaki Kawano, Mamoru Suzuki, Yasuteru Shigeta, Takato Yano, Motoyasu Adachi, et al. Neutron Crystallography of a Semiquinone Radical Intermediate of Copper Amine Oxidase Reveals a Substrate-Assisted Conformational Change of the Peptidyl Quinone Cofactor. ACS Catalysis. 2023. 12403-12413
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Takeshi Murakawa, Mamoru Suzuki, Kenji Fukui, Tetsuya Masuda, Michihiro Sugahara, Kensuke Tono, Tomoyuki Tanaka, So Iwata, Eriko Nango, Takato Yano, et al. Serial femtosecond X-ray crystallography of an anaerobically formed catalytic intermediate of copper amine oxidase. Acta Crystallographica Section D Structural Biology. 2022. 78. 12. 1428-1438
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Martina Pasqua, Marco Coluccia, Yoko Eguchi, Toshihide Okajima, Milena Grossi, Gianni Prosseda, Ryutaro Utsumi, Bianca Colonna. Roles of Two-Component Signal Transduction Systems in Shigella Virulence. Biomolecules. 2022. 12. 9. 1321-1321
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Mitsuo Shoji, Takeshi Murakawa, Shota Nakanishi, Mauro Boero, Yasuteru Shigeta, Hideyuki Hayashi, Toshihide Okajima. Molecular mechanism of a large conformational change of the quinone cofactor in the semiquinone intermediate of bacterial copper amine oxidase. Chemical Science. 2022. 13. 36. 10923-10938
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Takeshi Murakawa, Kazuo Kurihara, Motoyasu Adachi, Katsuhiro Kusaka, Katsuyuki Tanizawa, Toshihide Okajima. Re-evaluation of protein neutron crystallography with and without X-ray/neutron joint refinement. IUCrJ. 2022. 9. 3. 342-348
ｍore...
MISC (93)：
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斎藤遥, 大原ひかる, 小林勇気, 田中寛, 五十嵐雅之, 内海龍太郎, 岡島俊英, 華岡光正, 華岡光正. Cyanidioschyzon merolaeの光応答転写制御におけるヘムの関与. 日本農芸化学会関東支部講演要旨集(CD-ROM). 2022. 2022
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村川 武志, 岡島 俊英. 宙に浮く水素イオン?!-大型タンパク質の中性子結晶構造解析で見えた特異な世界-(4月28日、プレス発表). J-PARC News 第181号. 2020. 181. 2-2
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宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 量子科学技術研究開発機構. 2020
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銅アミン酸化酵素の中性子結晶構造解析に成功 -宙に浮いているようにみえる水素イオンなど初めて解明. 茨城大学. 2020
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宙に浮く水素イオン?! -大型タンパク質の中性子結晶構造解析で見えた特異な世界-. 大阪大学. 2020
ｍore...
Books (4)：
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Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology
CRC Press, FL, USA 2009
-
酵素ハンドブック第3版
朝倉書店 2008
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蛋白質科学
化学同人、京都 2006
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構造生物学 : ヌクレオシド-リン酸キナーゼ
朝倉書店 1997
Education (2)：
- - 1992 Osaka University
- - 1987 Tokyo University of Science Faculty of Science and Technology Applied Biological Science
Professional career (1)：
- (BLANK) (Osaka University)
Work history (5)：
- 2007/04 - 現在 大阪大学産業科学研究所 准教授
- 2002/11 - 2007/03 大阪大学産業科学研究所 助教授
- 2000/04 - 2002/11 Osaka University The Institute of Scientific and Industrial Research
- 1995/04 - 2000/03 Kindai University Faculty of Agriculture
- 1992/04 - 1995/03 Kindai University Faculty of Agriculture
Awards (2)：
- 2021/03 - 公益社団法人日本農芸化学会 第18回農芸化学研究企画賞
- 2017/04 - 長瀬科学技術振興財団 長瀬研究振興賞受賞
Association Membership(s) (4)：
日本蛋白科学会
, Protein Society
, 日本農芸化学会
, 日本生化学会
