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J-GLOBAL ID：201702238047778793   Reference number：17A0816504

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

癌型輸送体L型アミノ酸輸送体1(LAT1)の新系列の阻害剤の構造活性相関

Author (8)： Kongpracha Pornparn (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Nagamori Shushi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Wiriyasermkul Pattama (Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA) ,  Tanaka Yoko (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kaneda Kazuko (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Okuda Suguru (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Ohgaki Ryuichi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Kanai Yoshikatsu (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 133  Issue： 2  Page： 96-102  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Membrane Proteins ,...
Semi thesaurus term： cell physiology ,...

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Author keywords (4)： L-type amino acid transporter 1 (LAT1) ,  Inhibitor ,  Structure-activity relationship ,  Anti-cancer agent

JST classification (4)： Transport of cell membrane  (EF04020R) ,  Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (3)： SKN-103 ,  Triiodothyronine ,  Leucine

Reference (21)：

• Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev. 1990;70:43-77.
• Wang Q, Holst J. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015;5:1281-1294.
• Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, et al. Specific transport of 3-fluoro-L-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging. Cancer Sci. 2016;107:347-352.
• Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, et al. Transport of 3-fluoro-L-a-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [¹⁸F]FAMT positron emission tomography. J Pharmacol Sci. 2016;130:101-109.
• Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, et al. Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET. J Nucl Med. 2012;53:1253-1261.

Terms in the title (7)： 癌 ,  輸送体 ,  L型アミノ酸輸送体1 ,  LAT1 ,  系列 ,  阻害剤 ,  構造活性相関