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J-GLOBAL ID：201702243308707911   Reference number：17A1428903

CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility

CDKL5は海馬におけるGluN2B含有NMDA受容体のシナプス後局在化を制御し,発作感受性を調節する【Powered by NICT】

Author (19)： Okuda Kosuke (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Kobayashi Shizuka (Division of Neuronal Network, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan) ,  Fukaya Masahiro (Department of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan) ,  Watanabe Aya (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Murakami Takuto (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Hagiwara Mai (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Sato Tempei (Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan) ,  Ueno Hiroe (Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan) ,  Ogonuki Narumi (Bioresource Engineering Division, RIKEN BioResource Center, Tsukuba 305-0074, Japan) ,  Komano-Inoue Sayaka (Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Manabe Hiroyuki (Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Yamaguchi Masahiro (Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Ogura Atsuo (Bioresource Engineering Division, RIKEN BioResource Center, Tsukuba 305-0074, Japan) ,  Asahara Hiroshi (Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan) ,  Asahara Hiroshi (Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, USA) ,  Sakagami Hiroyuki (Department of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan) ,  Mizuguchi Masashi (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan) ,  Manabe Toshiya (Division of Neuronal Network, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan) ,  Tanaka Teruyuki (Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan)
Material： Neurobiology of Disease  (Neurobiol Dis)
Volume： 106  Page： 158-170  Publication year： 2017 
JST Material Number： W1774A  ISSN： 0969-9961  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Mutations in the Cyclin-depend...

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Thesaurus term： knockout mouse ,  *sensitivity ,  mRNA ,  excitation (physiology) ,  *synapse ,  *Eumetopias jubata ,  Proteins ,  gene ,  *NMDA receptor ,  Pathology ,  subcellular distribution ,  *seizure (disease) ,  Up-Regulation ,  *GluN2B ,  laboratory animal ,  Mus musculus ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  secondary amine

Author keywords (9)： CDKL5 ,  Developmental disorders ,  Epilepsy ,  Hippocampus ,  Excitatory synapses ,  NMDA receptors ,  GluN2B ,  SAP102 ,  Ifenprodil

JST classification (3)： Receptors on cell membrane  (EF04030C) ,  Cell physiology in general  (EF02010S) ,  Nervous system in general  (EJ12010J)

Substance index (1)： NMDA

Terms in the title (8)： 海馬 ,  GluN2B ,  NMDA受容体 ,  シナプス ,  局在化 ,  発作 ,  感受性 ,  調節