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J-GLOBAL ID：201702245308937037   Reference number：17A1693105

Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori

Helicobacter pyloriの代替メナキノン生合成経路を標的とした狭いスペクトラムの阻害剤

Author (13)： Yamamoto Tsuyoshi (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Matsui Hidenori (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Matsui Hidenori (Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Yamaji Kenzaburo (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Takahashi Tetsufumi (Graduate School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Overby Anders (Graduate School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Nakamura Masahiko (Graduate School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Matsumoto Atsuko (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Nonaka Kenichi (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Sunazuka Toshiaki (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Sunazuka Toshiaki (Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Omura Satoshi (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Nakano Hirofumi (Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan)
Material： Journal of Infection and Chemotherapy  (J Infect Chemother)
Volume： 22  Issue： 9  Page： 587-592  Publication year： Sep. 2016 
JST Material Number： L2852A  ISSN： 1341-321X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Helicobacter pylori ,...
Semi thesaurus term： menaquinone ,...

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Author keywords (6)： Alternative menaquinone biosynthetic pathway ,  Narrow-spectrum anti-Helicobacter pylori compounds ,  Polyunsaturated fatty acids ,  Mouse infection model ,  Siamycin I ,  Futalosine

JST classification (1)： Basic research of antibacterial drugs  (GW17020S)

Substance index (3)： Eicosapentaenoic Acid ,  Docosahexaenoic acid ,  Futalosine

Reference (45)：

• Kurosu M, Begari E. Vitamin K2 in electron transport system: are enzymes involved in vitamin K2 biosynthesis promising drug target? Molecules 2010;15:1531-53.
• Bentley R, Meganathan R. Biosynthesis of vitamin K (menaquinone) in bacteria. Microbiol Rev 1982;46:241-80.
• Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Ito N, Seto H, et al. An alternative menaquinone biosynthetic pathway operating in microorganisms. Science 2008;321:1670-3.
• Dairi T. An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains. J Antibiot 2009;62:347-52.
• Zhi XY, Yao JC, Tang SK, Huang Y, Li HW, Li WJ. The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote evolution. Genome Biol Evol 2014;6:149-60.

Terms in the title (7)： Helicobacter ,  代替 ,  メナキノン ,  生合成経路 ,  標的 ,  スペクトラム ,  阻害剤