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J-GLOBAL ID：201702258505069311   Reference number：17A0386482

Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti

Mesorhizobium loti由来2-メチル-3-ヒドロキシピリジン-5-カルボン酸オキシゲナーゼのTyr270残基の役割

Author (8)： Kobayashi Jun (Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasyo, Uji, Kyoto 611-0011, Japan) ,  Yoshida Hiromi (Division of Structural Biology, Life Science Research Center and Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kitagun, Kagawa 761-0793, Japan) ,  Yagi Toshiharu (Faculty of Agriculture and Agricultural Science Program, Graduate School of Integral Arts and Science, Kochi University, Nankoku, Kochi 783-8502, Japan) ,  Kamitori Shigehiro (Division of Structural Biology, Life Science Research Center and Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kitagun, Kagawa 761-0793, Japan) ,  Hayashi Hideyuki (Department of Chemistry, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki 569-8686, Japan) ,  Mizutani Kimihiko (Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasyo, Uji, Kyoto 611-0011, Japan) ,  Takahashi Nobuyuki (Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasyo, Uji, Kyoto 611-0011, Japan) ,  Mikami Bunzo (Laboratory of Applied Structural Biology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Gokasyo, Uji, Kyoto 611-0011, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 123  Issue： 2  Page： 154-162  Publication year： Feb. 2017 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *flavin enzyme ,...
Semi thesaurus term： Rhizobium ,...

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Author keywords (6)： Key words Mesorhizobium loti ,  Vitamin B₆ degradation pathway I ,  Pyridine-ring opening reaction ,  Flavoenzyme ,  2-Methyl-3-hydroxypyridine-5-carboxylic acid oxygenase ,  Tyr270

JST classification (3)： Microorganism biochemistry  (EG03020N) ,  Enzyme in general  (EB09010D) ,  Molecular structure  (EB03020Y)

Substance index (3)： 5-Hydroxy-6-methylnicotinic acid ,  5-Hydroxynicotinic acid ,  4-Pyridoxic acid

Reference (23)：

• Nagase, T., Mugo, A. N., Chu, H. N., Yoshikane, Y., Ohnishi, K., and Yagi, T.: The mll6786 gene encodes a repressor protein controlling the degradation pathway for vitamin B₆ in Mesorhizobium loti, FEMS Microbiol. Lett., 329, 116-122 (2012).
• Sparrow, L G., Ho, P. P. K., Sundaram, T. K., Zach, D., Nyns, E. J., and Snell, E. E.: The bacterial oxidation of vitamin B₆: VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypridine ring, J. Biol. Chem., 244, 2590-2600 (1969).
• Kishore, M. G. and Snell, E. E.: Kinetic investigations on a flavoprotein oxygenase, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, J. Biol. Chem., 256, 4228-4233 (1981).
• Yuan, B., Yokochi, N., Yoshikane, Y., Ohnishi, K., and Yagi, T.: Molecular cloning, identification and characterization of 2-methyl-3-hydroxypyridine-5-carboxylic-acid- dioxygenase-coding gene from nitrogen-fixing symbiotic bacterium Mesorhizobium loti, J. Biosci. Bioeng., 102, 504-510 (2006).
• Chayien, P.: Flavoenzyme catalyzing oxidative aromatic ring-cleavage reactions, Arch. Biochem. Biophys., 493, 62-70 (2009).

Terms in the title (6)： Mesorhizobium ,  3-ヒドロキシピリジン ,  カルボン酸 ,  オキシゲナーゼ ,  残基 ,  役割