Art

J-GLOBAL ID：201702271405878577   Reference number：17A0518519

Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production

GalNAc-T6による過剰なAPP O-グリコシル化により,アミロイドβ蛋白質生成を低減する

Author (14)： AKASAKA-MANYA Keiko (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  KAWAMURA Masaki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  KAWAMURA Masaki (Tokyo Metropolitan Univ., Tokyo, JPN) ,  TSUMOTO Hiroki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  SAITO Yuko (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  TACHIDA Yuriko (RIKEN, Saitama, JPN) ,  KITAZUME Shinobu (RIKEN, Saitama, JPN) ,  HATSUTA Hiroyuki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  MIURA Yuri (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  HISANAGA Shin-ichi (Tokyo Metropolitan Univ., Tokyo, JPN) ,  MURAYAMA Shigeo (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  HASHIMOTO Yasuhiro (Fukushima Medical Univ., Fukushima City, JPN) ,  MANYA Hiroshi (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  ENDO Tamao (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 161  Issue： 1  Page： 99-111  Publication year： Jan. 2017 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Alzheimer disease ,...
Semi thesaurus term： HEK293T cell ,...

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JST classification (3)： Basic neurology  (GN01020W) ,  Enzyme in general  (EB09010D) ,  Proteins and peptides in general  (EB03010N)

Reference (46)：

• LaFerla, F.M., Green, K.N., and Oddo, S. (2007). Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 8, 499-509
• Selkoe, D.J., and Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8, 595-608
• Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J.M., Masters, C.L., and Beyreuther, K. (1989). Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126
• Tomita, S., Kirino, Y., and Suzuki, T. (1998). Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. J. Biol. Chem. 273, 6277-6284
• Sato, Y., Liu, C., Wojczyk, B.S., Kobata, A., Spitalnik, S.L., and Endo, T. (1999). Study of the sugar chains of recombinant human amyloid precursor protein produced by Chinese hamster ovary cells. Biochim. Biophys. Acta 1472, 344-358

Terms in the title (3)： APP ,  O-グリコシル化 ,  アミロイドβ蛋白質