Art

J-GLOBAL ID：201702279154795732   Reference number：17A0269766

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V) : coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens

ヒト成人T細胞白血病/リンパ腫に対する植物由来の有望な化学療法剤候補のスクリーニング(V):Boenninghausenia japonicaおよびRuta graveolens由来のクマリンおよびアルカロイド

Author (9)： NAKANO Daisuke (Fukuoka Univ., Fukuoka, JPN) ,  ISHITSUKA Kenji (Kagoshima Univ., Kagoshima, JPN) ,  MATSUDA Narumi (Fukuoka Univ., Fukuoka, JPN) ,  KOUGUCHI Ai (Fukuoka Univ., Fukuoka, JPN) ,  TSUCHIHASHI Ryota (Fukuoka Univ., Fukuoka, JPN) ,  OKAWA Masafumi (Fukuoka Univ., Fukuoka, JPN) ,  OKABE Hikaru (Fukuoka Univ., Fukuoka, JPN) ,  TAMURA Kazuo (Fukuoka Univ., Fukuoka, JPN) ,  KINJO Junei (Fukuoka Univ., Fukuoka, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 71  Issue： 1  Page： 170-180  Publication year： 2017 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： T cell leukemia ,...
Semi thesaurus term： Boenninghausenia japonica ,...

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JST classification (2)： Plant biochemistry  (EH01050J) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (15)： Graveoline ,  1-Methyl-2-(4-(1,3-benzodioxole-5-yl)butyl)quinoline-4(1H)-one ,  1-Methyl-2-(6-(1,3-benzodioxole-5-yl)hexyl)quinoline-4(1H)-one ,  1-Methyl-2-nonylquinolin-4(1H)-one ,  2-(1-Methyl-1-acetoxyethyl)-6-(1,1-dimethylallyl)-9-hydroxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one ,  2-(1-Methyl-1-hydroxyethyl)-6-(1,1-dimethylallyl)-9-hydroxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one ,  2-(1-Methyl-1-hydroxyethyl)-9-hydroxy-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one ,  2-(4-(1,3-Benzodioxole-5-yl)butyl)quinoline-4(1H)-one ,  2-Nonylquinolin-4(1H)-one ,  Isopimpinellin ,  Bergapten ,  Chalepensin ,  Ficusin ,  Matsukaze lactone ,  Dihydroxanthyletin

Reference (37)：

• Ishitsuka K, Tamura K (2008) Treatment of adult T-cell leukemia/lymphoma: past, present, and future. Eur J Haematol 80:185-196
• Nakano D, Ishitsuka K, Hatsuse T, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J (2011) Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: active principles structure-activity relationships with withanolides. J Nat Med 65:559-567
• Nakano D, Ishitsuka K, Katsuya H, Kunami N, Nogami R, Yoshimura Y, Matsuda M, Kamikawa M, Tsuchihashi R, Okawa M, Ikeda T, Nohara T, Tamura K, Kinjo J (2013) Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure-activity relationships with withanolides isolated from solanaceous plants. J Nat Med 67:415-420
• Nakano D, Ishitsuka K, Kamikawa M, Matsuda M, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J (2013) Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (III). J Nat Med 67:894-903
• Nakano D, Ishitsuka K, Ikeda M, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J (2015) Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (IV): phenanthroindolizidine alkaloids from Tylophora tanakae leaves. J Nat Med 69:397-401

Terms in the title (9)： ヒト ,  成人T細胞白血病 ,  リンパ腫 ,  植物 ,  化学療法剤 ,  スクリーニング ,  Ruta ,  クマリン ,  アルカロイド