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J-GLOBAL ID：201702298530849423   Reference number：17A0450552

Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer

フルベストラント耐性乳癌の運命に関与するERαの異なる後成的機構【Powered by NICT】

Author (12)： Tsuboi Kouki (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Kaneko Yosuke (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Nagatomo Takamasa (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Fujii Rika (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Fujii Rika (Surgical Oncology, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Hanamura Toru (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Hanamura Toru (Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Nagano, Japan) ,  Gohno Tatsuyuki (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Yamaguchi Yuri (Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan) ,  Niwa Toshifumi (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Hayashi Shin-ichi (Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan) ,  Hayashi Shin-ichi (Center for Regulatory Epigenome and Diseases, Graduate Tohoku University School of Medicine, Sendai, Japan)
Material： Journal of Steroid Biochemistry & Molecular Biology  (Journal of Steroid Biochemistry and Molecular Biology)
Volume： 167  Page： 115-125  Publication year： 2017 
JST Material Number： C0595A  ISSN： 0960-0760  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Approximately 70% of breast ca...

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Thesaurus term： mRNA ,  *epigenetics ,  antiestrogen ,  methylation ,  *breast tumor ,  promoter(genetics) ,  MCF7 cell ,  cell proliferation ,  phosphorylation
Semi thesaurus term： 阻害剤 ,  DNAメチル化 ,  遺伝子発現調節 ,  細胞株 ,  乳癌細胞 ,  *エストロゲン受容体α , 【Automatic Indexing@JST】

Author keywords (5)： Breast cancer ,  Fulvestrant ,  Estrogen receptor α ,  DNA methylation ,  Endocrine therapy resistance

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Sex hormones  (EB08050O)

Terms in the title (5)： フルベストラント ,  耐性 ,  乳癌 ,  ERα ,  後成的機構