Sakamoto Takashi

サカモトタカシ | Sakamoto Takashi

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://sites.google.com/view/sakamotolab/home

Research field (2)： Bioorganic chemistry , Chemical biology

Research theme for competitive and other funds (8)：

2021 - 2024 三脚型キノン-シアニン色素の特徴を活かした4重鎖核酸イメージング蛍光色素の開発
2017 - 2020 超高速光クロスリンクを用いたゲノム操作法の開発
2015 - 2017 DNA捕捉・放出能力をもつ多機能性ペプチド・ゲル・リポソームの創出
2015 - 2017 Development of a simultaneous detection system for nucleic acids using ratiometric NMR molecular probes
2014 - 2017 Development about photochemical detection of nuceic acids by 19F-NMR

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Papers (63)：

Takashi Sakamoto. Live-Cell Imaging of RNA G-Quadruplex with a Dual-Color Fluorescence Switch-on Probe. Methods in molecular biology (Clifton, N.J.). 2025. 2875. 83-90
Junya Muramoto, Takashi Sakamoto. Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death. Molecules. 2024
Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, Takashi Sakamoto. Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift. Analytical Chemistry. 2023. 95. 47. 17162-17165
Takashi Sakamoto, Zehui Yu. Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex. Chemistry Letters. 2022. 51. 12. 1139-1142
Takashi Sakamoto, Zehui Yu, Yuto Otani. Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells. Analytical Chemistry. 2022. 94. 10. 4269-4276

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MISC (49)：

村岡優香, 安原優, 岩井まり奈, 坂本隆, 坂本隆. Regulating the binding selectivity of dual-color fluorescence switch-on probe that responses with duplex and quadruplex DNA. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
三輪好輝, 坂本隆. Development of photochromic DNA imaging probe whose fluorescence properties can be regulated by photoirradiation. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
坂本隆, 坂本隆, YU Zehui, 大谷悠人. Simultaneous detection of double-stranded and G4 DNAs using a tripodal quinone-cyanine dye. 日本化学会春季年会講演予稿集(Web). 2021. 101st
坂本隆. Development of a thin layer made of fluorescence turn-on DNA probe and the application for micro-RNA detections. サムコ科学技術振興財団研究報告集. 2021. 3
坂本隆, 山田陸斗. Label-free in situ Monitoring of DNA Hybridization Chain Reaction Using Sequence-Selective Interaction of Groove Binders with Double-Stranded DNAs. 日本化学会春季年会講演予稿集(CD-ROM). 2020. 100th

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Patents (17)：

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Books (2)：

Lectures and oral presentations (76)：

3脚型キノンーシアニン色素の光増感活性によるガン細胞選択的アポトーシス誘導
(第18回バイオ関連化学シンポジウム 2024)
4重鎖核酸選択的キノン-シアニン色素リガンドによる細胞死の光誘導
(第34回バイオ・高分子シンポジウム 2024)
3脚型キノンーシアニン色素への光照射により生成する活性酸素によるアポトーシス誘導
(日本ケミカルバイオロジー学会第18回年会 2024)
Increased sensitivity of HCR-based nucleic acid detection using the concentration effect of microbeads
(2024)
核酸4重鎖と2重鎖を見分ける近赤外蛍光プローブ
(分子夾雑に挑む化学@和歌山 2023)

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Education (1)：

2001 - 2005 Kyoto Institute of Technology Graduate School of Science and Technology

Professional career (1)：

Work history (4)：

2016/10 - 現在 Wakayama University Graduate School of Systems Engineering
2009/06 - 2016/09 Japan Advanced Institute of Science and Technology
2007/04 - 2009/05 京都大学大学院工学研究科博士研究員
2005/04 - 2007/03 Kyoto Institute of Technology Graduate School of Science and Technology

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