Research theme for competitive and other funds (23)：
2024 - 2027 Endothelial cell glycocalyx special focus on hyaluronic acid to elucidate the pathogenesis of kidney disease and its clinical application.
2024 - 2027 腎疾患におけるlncRNAの役割の解明と新規治療法の開発
2023 - 2026 過剰塩分摂取に起因するCKDにみられる炎症の全身臓器障害の病態解明
2022 - 2025 内皮細胞障害に着目したCKD血管石灰化メカニズムの解析と標的治療の確立
2022 - 2025 Analysis of pathogenesis associated with mutation of complement associated gene and autoantibodies in development/progression of C3 nephropathy.
2021 - 2024 内皮細胞Glycocalyxをターゲットとした腎疾患の新たな治療戦略の確立
2021 - 2024 Elucidation of the mechanism of peritoneal dialysis-related peritoneal injury through complement pathway and establishment of novel anti-complement therapy.
2021 - 2024 腹膜透析におけるガス状伝達物質を用いた新たな腹膜劣化予防・治療法の開発
2019 - 2022 Application of gas mediator delivery system for the expanded criteria donor organs
2019 - 2022 Elucidation of the pathophysiology of secondary thrombotic microangiopathy (TMA) focusing on complement activity and glycan abnormalities
2018 - 2021 慢性腎不全における栄養障害・筋肉量低下の病態解明と治療戦略
2018 - 2021 Roles of the complement system to develop peritoneal inures in PD
2018 - 2021 Investigation of the mechanism and risk factors of encapsulating peritoneal sclerosis using peritoneal tissue pathological analysis
2018 - 2021 腹膜透析における除水不全、腹膜機能障害の病態解明と新たな治療戦略
2015 - 2018 Establishment of a new treatment strategy targeting inflammation for patients with chronic renal failure
2015 - 2018 PD-related peritonitis, especially fungal peritonitis, and peritoneal injuries associated with impairment of the complement system
2015 - 2018 腎疾患領域におけるリンパ管新生の観点からの病態解明とその治療戦略
2014 - 2017 Identification of novel biomarkers for early diagnosis and monitoring of cardio-renal syndrome in chronic kidney disease
2012 - 2015 Studies of complement-related mechanisms and possibilities of anti-complement therapy for peritoneal injuries under PD therapy
2009 - 2011 Complement-associated analysis for improvement of prognosis in patients on long-term peritoneal dialysis
2007 - 2008 Development of peritoneal sclerosis which is a serious complication in patients on peritoneal dialysis and possibilities of anti-compliment therapy as a therapy for peritoneal injuries
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Papers (233)：
Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, et al. In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney. Molecular therapy. Nucleic acids. 2025. 36. 1. 102387-102387
Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Shogo Banno, Yasuhiko Ito, Takuji Ishimoto. Assessing the Effect of Avacopan on Increasing ANCA Titres During Remission Maintenance in ANCA-Associated Vasculitis. International journal of rheumatic diseases. 2025. 28. 3. e70183
Genri Tagami, Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Takahiro Imaizumi, Shogo Banno, Yasuhiko Ito, et al. Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan. BMC rheumatology. 2025. 9. 1. 8-8
Takahiro Imaizumi, Takeshi Hasegawa, Takaaki Kosugi, Hiroki Nishiwaki, Masanori Abe, Norio Hanafusa, Hirokazu Honda, Kazuhiko Tsuruya, Yasuhiko Ito, Takahiro Kuragano. Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis. Scientific reports. 2025. 15. 1. 2689-2689
Takayuki Kambe, Makoto Yamaguchi, Takayuki Katsuno, Hirokazu Sugiyama, Keisuke Kamiya, Kentaro Imai, Hiroshi Kinashi, Shogo Banno, Yasuhiko Ito, Takuji Ishimoto. Isolated central nervous system lymphomatoid granulomatosis in an older adult patient with systematic lupus erythematosus: A case report. Modern rheumatology case reports. 2024
International Society of Nephrology
, American Society of Nephrology
, THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPAN COLLEGE OF RHEUMATOLOGY
, JAPANESE SOCIETY OF NEPHROLOGY
