Komatsu Toshihiro

コマツトシヒロ | Komatsu Toshihiro

Affiliation and department：

Research field (1)： Immunology

Research keywords (4)：抗原提示 , MHC , 血管内皮細胞 , T細胞

Research theme for competitive and other funds (6)：

2025 - 2028 Peptide immunotherapy targeting FAP-positive fibroblasts for tumors and fibrotic diseases
2023 - 2025 腫瘍内への制御性T細胞の抗原特異的浸潤機構の解明
2019 - 2022 Rational design of the next-generation peptide immunotherapy which exploits tumor endothelial cells as an APC.
2018 - 2021 Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironment
2016 - 2021 Generation of neo-self peptides in tumors

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Papers (7)：

Takashi Karashima, Toshihiro Komatsu, Shinkuro Yamamoto, Kaya Atagi, Hatsune Hashida, Hideo Fukuhara, Kenji Tamura, Shingo Ashida, Taro Shuin, Keiko Udaka, et al. Transcutaneous Imiquimod Combined With Anti-Programmed Cell Death-1 Monoclonal Antibody Extends the Survival of Mice Bearing Renal Cell Carcinoma. Cancer Medicine. 2025. 14. 10
Koji Nagaoka, Changbo Sun, Yukari Kobayashi, Takayuki Kanaseki, Serina Tokita, Toshihiro Komatsu, Kazuhiro Maejima, Junichiro Futami, Sachiyo Nomura, Keiko Udaka, et al. Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy. Cancers. 2021. 14. 1
Toshihiro Komatsu, Takeyuki Shimizu, Makoto Kanoh, Tomoya Miyakawa, Yoko Satta, Yoshiki Yasukochi, Rika Fujimoto, Motoki Tada, Kaori Machida, Sayo Kataoka, et al. Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Immunogenetics. 2020. 72. 3. 143-153
Hirofumi Nishikawa, Yoshinori Taniguchi, Tatsuki Matsumoto, Naoki Arima, Mamoru Masaki, Yoshiko Shimamura, Kosuke Inoue, Taro Horino, Shimpei Fujimoto, Kentaro Ohko, et al. Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines. Kidney international. 2018. 93. 3. 599-614
Yuta Yoshizaki, Eiji Yuba, Toshihiro Komatsu, Keiko Udaka, Atsushi Harada, Kenji Kono. Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes. Molecules (Basel, Switzerland). 2016. 21. 10

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MISC (56)：

Keiko Udaka, Toshihiro Komatsu, Yuki Tanaka, Kazuhide Onoguchi, Yoshiko Yamashita, Ryo Tanaka, Yoichiro Iwase. Peptide immunotherapy targeting FAP-positive fibroblasts augments tumor antigen-specific immunotherapy. 日本がん免疫学会総会プログラム・抄録集. 2025. 29th. 212
Peptide immunotherapy targeting FAP-positive fibroblasts. 日本免疫学会総会・学術集会記録(CD-ROM). 2024. 53. ROMBUNNO.WS29-21-P
辛島尚, 小松利広, 山本新九郎, 橋田初音, 執印太郎, 宇高恵子, 井上啓史. 腎癌におけるイミキモド経皮投与と抗-programmed cell death-1抗体の併用療法. 日本癌治療学会学術集会(Web). 2024. 62nd. ROMBUNNO.P6-7 (WEB ONLY)
辛島尚, 小松利広, 山本新九郎, 橋田初音, 執印太郎, 宇高恵子, 井上啓史. 腎癌におけるイミキモド経皮投与と抗-programmed cell death-1抗体の併用療法. 腎癌研究会会報. 2024. 54. 30
宇高恵子, 小松利広, 佃美奈, 清水健之, 田中雄希, 尾上広祐, 山下慶子, 小野口和英, 田中領, 岩瀬陽一郎. 悪性腫瘍に対するペプチド免疫療法に対するVEGF阻害療法の影響. 日本がん免疫学会総会プログラム・抄録集. 2024. 28th. 172

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