Hayashi Junsuke

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：有機化学 , 核酸化学

Research theme for competitive and other funds (2)：

2021 - 2024 Development of therapeutic strategies for the realization of tumor suppressive microRNA replacement therapy for refractory solid tumors
2015 - 2017 RNA干渉の作用長期化を目指した新規プロドラッグ型siRNAの開発

Papers (16)：

Junsuke Hayashi, Yosuke Ochi, Kota Senpuku, Shun-Ichi Wada, Fumito Wada, Mariko Harada-Shiba, Hidehito Urata. Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency. Bioorganic & medicinal chemistry. 2024. 104. 117693-117693
Norihito Sugimoto, Junsuke Hayashi, Ryohei Funaki, Shun-Ichi Wada, Fumito Wada, Mariko Harada-Shiba, Hidehito Urata. Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment. Chembiochem : a European journal of chemical biology. 2023. e202300526
Shun-Ichi Wada, Akira Shibaike, Junsuke Hayashi, Hidehito Urata. Influence of Aib-Containing Amphipathic Helical Chain Length in MAP(Aib)-cRGD as Carrier for siRNA Delivery. Chemistry & biodiversity. 2022. 19. 2. e202100728
Kohei Taniguchi, Shun-Ichi Wada, Yuko Ito, Junsuke Hayashi, Yosuke Inomata, Sang-Woong Lee, Tomohito Tanaka, Kazumasa Komura, Yukihiro Akao, Hidehito Urata, et al. α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro. Molecular pharmaceutics. 2019. 16. 11. 4542-4550
Shun-Ichi Wada, Kohei Taniguchi, Hiroaki Hamazaki, Azusa Yamada, Junsuke Hayashi, Kazuhisa Uchiyama, Hidehito Urata. Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells. Bioorganic & medicinal chemistry letters. 2019. 29. 15. 1934-1937

ｍore...

MISC (2)：

Lectures and oral presentations (22)：

MAP(Aib)のArg置換によるsiRNA細胞内デリバリーへの影響
(日本薬学会第143年会 2023)
ヌクレアーゼ抵抗性改善を目指した部分修飾ApoB標的プロドラッグ型siRNAの設計
(日本薬学会第143年会 2023)
細胞膜透過性ペプチド-5-アミノレブリン酸複合体の合成
(第72回日本薬学会関西支部総会・大会 2022)
細胞膜透過性ペプチドMAP (Aib) のArg置換体の合成とsiRNAの細胞内デリバリー効果
(第72回日本薬学会関西支部総会・大会 2022)
五員環ジスルフィドを含むホスホトリエステル修飾核酸の合成
(第72回日本薬学会関西支部総会・大会 2022)

ｍore...

Professional career (1)：

Work history (3)：

Awards (1)：

Association Membership(s) (3)：

日本核酸化学会 , NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page