Ohno Akiko

Research theme for competitive and other funds (9)：

2018 - 2020 カテキン三量体を創薬シードとした新規アルツハイマー病治療薬の開発
2018 - 2020 生体影響予測を基盤としたナノマテリアルの統合的健康影響評価方法の提案
2014 - 2017 ?アミロイドβを標的としたアルツハイマー病治療薬の開発
2008 - 2012 フェノール性抗酸化剤をテンプレートとした生活習慣病の予防および治療薬の開発
2008 - 2012 多層的疾患オミックス解析におけるメタボローム情報に基づく創薬標的の網羅的探索を目指した研究

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Papers (25)：

Kiyoshi Fukuhara, Akiko Ohno, Ruri Kikura-Hanajiri. A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using 1H-NMR Spectroscopy. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017. 137. 9. 1147-1154
Takuya Arai, Akiko Ohno, Kazunori Mori, Hiroshi Kuwata, Mirei Mizuno, Kohei Imai, Shuntaro Hara, Motoko Shibanuma, Masaaki Kurihara, Naoki Miyata, et al. Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides. Bioorganic & medicinal chemistry letters. 2016. 26. 22. 5468-5471
Takuya Arai, Akiko Ohno, Mori Kazunori, Taeko Kakizawa, Hiroshi Kuwata, Toshihiko Ozawa, Motoko Shibanuma, Shuntaro Hara, Seiichi Ishida, Masaaki Kurihara, et al. Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. Bioorganic & medicinal chemistry. 2016. 24. 18. 4138-4143
Imai, Kohei, Nakanishi, Ikuo, Ohno, Akiko, Kurihara, Masaaki, Miyata, Naoki, Matsumoto, Ken-Ichiro, Nakamura, Asao, Fukuhara, Kiyoshi. Synthesis and radical-scavenging activity of a dimethyl catechin analogue. Bioorganic & medicinal chemistry letters. 2014. 11. 24. 2582-2584
Fukuhara, Kiyoshi, Ohno, Akiko, Ota, Yosuke, Senoo, Yuya, Maekawa, Keiko, Okuda, Haruhiro, Kurihara, Masaaki, Okuno, Alato, Niida, Shumpei, Saito, Yoshiro, et al. NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers. Journal of clinical biochemistry and nutrition. 2013. 2. 52. 133-138

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