Art

J-GLOBAL ID：201802211897978100   Reference number：18A1691340

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

NUDT15コドン139は炎症性腸疾患の日本人患者におけるチオプリン誘発重度有害事象を予測する最高の薬理遺伝学的マーカーである:多施設研究

Author (40)： KAKUTA Yoichi (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  KAWAI Yosuke (Tohoku Univ., Sendai, JPN) ,  KAWAI Yosuke (Univ. Tokyo, Tokyo, JPN) ,  OKAMOTO Daisuke (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  TAKAGAWA Tetsuya (Hyogo Coll. of Medicine, Nishinomiya, JPN) ,  IKEYA Kentaro (Hamamatsu South Hospital, Hamamatsu, JPN) ,  SAKURABA Hirotake (Hirosaki Univ. Graduate School of Medicine, Hirosaki, JPN) ,  NISHIDA Atsushi (Shiga Univ. Medical Sci., Otsu, JPN) ,  NAKAGAWA Shoko (Aichi Medical Univ. School of Medicine, Nagakute, JPN) ,  MIURA Miki (Kyorin Univ. School of Medicine, Mitaka, JPN) ,  TOYONAGA Takahiko (Kitasato Univ. Kitasato Inst. Hospital, Tokyo, JPN) ,  ONODERA Kei (Sapporo Medical Univ. School of Medicine, Sapporo, JPN) ,  SHINOZAKI Masaru (Univ. Tokyo, Tokyo, JPN) ,  ISHIGURO Yoh (Hirosaki National Hospital, Hirosaki, JPN) ,  MIZUNO Shinta (Keio Univ. School of Medicine, Tokyo, JPN) ,  TAKAHARA Masahiro (Okayama Univ. Graduate School of Medicine, Dentistry, and Pharmaceutical Sci., Okayama, JPN) ,  YANAI Shunichi (Iwate Medical Univ., Morioka, JPN) ,  HOKARI Ryota (National Defense Medical Coll., Tokorozawa, JPN) ,  NAKAGAWA Tomoo (Chiba Univ., Chiba, JPN) ,  ARAKI Hiroshi (Gifu Univ. Hospital, Gifu, JPN) ,  MOTOYA Satoshi (Sapporo-Kosei General Hospital, Sapporo, JPN) ,  NAITO Takeo (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  MOROI Rintaro (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  SHIGA Hisashi (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  ENDO Katsuya (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  KOBAYASHI Taku (Kitasato Univ. Kitasato Inst. Hospital, Tokyo, JPN) ,  NAGANUMA Makoto (Keio Univ. School of Medicine, Tokyo, JPN) ,  HIRAOKA Sakiko (Okayama Univ. Graduate School of Medicine, Dentistry, and Pharmaceutical Sci., Okayama, JPN) ,  MATSUMOTO Takayuki (Iwate Medical Univ., Morioka, JPN) ,  NAKAMURA Shiro (Hyogo Coll. of Medicine, Nishinomiya, JPN) ,  NAKASE Hiroshi (Sapporo Medical Univ. School of Medicine, Sapporo, JPN) ,  HISAMATSU Tadakazu (Kyorin Univ. School of Medicine, Mitaka, JPN) ,  SASAKI Makoto (Aichi Medical Univ. School of Medicine, Nagakute, JPN) ,  HANAI Hiroyuki (Hamamatsu South Hospital, Hamamatsu, JPN) ,  ANDOH Akira (Shiga Univ. Medical Sci., Otsu, JPN) ,  NAGASAKI Masao (Tohoku Univ., Sendai, JPN) ,  KINOUCHI Yoshitaka (Tohoku Univ., Sendai, JPN) ,  SHIMOSEGAWA Tooru (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  MASAMUNE Atsushi (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  SUZUKI Yasuo (Toho Univ. Sakura Medical Center, Sakura, JPN)
Material： Journal of Gastroenterology  (J Gastroenterol)
Volume： 53  Issue： 9  Page： 1065-1078  Publication year： 2018 
JST Material Number： Z0748A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： ROC analysis ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1691340&from=J-GLOBAL&jstjournalNo=Z0748A") }}

JST classification (1)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (3)： 6-Mercaptopurine ,  Azathioprine ,  Salazosulfapyridine

Reference (31)：

• Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 2018;53(3):305-53.
• Hibi T, Naganuma M, Kitahora T, Kinjyo F, Shimoyama T. Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. J Gastroenterol. 2003;38(8):740-6.
• Khan KJ, Dubinsky MC, Ford AC, Ullman TA, Talley NJ, Moayyedi P. Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):630-42.
• Panaccione R, Ghosh S, Middleton S, Marquez JR, Scott BB, Flint L, et al. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis. Gastroenterology. 2014;146(2):392-400.
• Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;362(15):1383-95.

Terms in the title (13)： NUDT15 ,  コドン ,  炎症性腸疾患 ,  日本人 ,  患者 ,  チオプリン ,  誘発 ,  重度有害事象 ,  予測 ,  薬理遺伝学 ,  マーカー ,  施設 ,  研究