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J-GLOBAL ID：201802216773061927   Reference number：18A0569398

A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T-cell receptors exhibiting different levels of cross-reactivity

CDR3ループ動力学の研究は異なるレベルの交差反応性を示すT細胞受容体によるペプチド認識の異なる機構を明らかにする【Powered by NICT】

Author (4)： Tsuchiya Yuko (Institute for Protein Research, Osaka University, Suita, Osaka, Japan) ,  Namiuchi Yoshiki (RIKEN Quantitative Biology Centre, Suita, Osaka, Japan) ,  Wako Hiroshi (School of Social Sciences, Waseda University, Tokyo, Japan) ,  Tsurui Hiromichi (Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan)
Material： Immunology
Volume： 153  Issue： 4  Page： 466-478  Publication year： 2018 
JST Material Number： H0768A  ISSN： 0019-2805  CODEN： IMMUAM  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： T-cell receptors (TCRs) can pr...

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Thesaurus term： *T cell receptor ,  interface (surface) ,  Entropy ,  *peptide ,  hydrogen bond ,  interaction ,  *T cell ,  degeneracy ,  complex (substance) ,  complex (compound) ,  binding affinity ,  *cross reactivity ,  *CDR3
Semi thesaurus term： 特異性 , 【Automatic Indexing@JST】

Author keywords (5)： binding affinity-interface area relationship ,  CH-π interactions ,  cross-reactive T-cell receptor recognition ,  fragment molecular orbital method ,  molecular dynamics simulation

JST classification (1)： Immunological reaction in general  (ED03010T)

Terms in the title (7)： CDR3 ,  ループ ,  動力学 ,  研究 ,  交差反応性 ,  T細胞受容体 ,  ペプチド