Art

J-GLOBAL ID：201802218791969724   Reference number：18A0368639

Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics

細胞内および細胞外アミノ酸メタボロミクスを用いるグルコース枯渇条件下の膵癌細胞に対する抗癌薬作用の評価

Author (8)： Tomita Ryoko (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Todoroki Kenichiro (Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka) ,  Hayama Tadashi (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Yoshida Hideyuki (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Fujioka Toshihiro (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Nakashima Manabu (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Yamaguchi Masatoshi (Faculty of Pharmaceutical Sciences, Fukuoka University) ,  Nohta Hitoshi (Faculty of Pharmaceutical Sciences, Fukuoka University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 2  Page： 220-228(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *analysis ,...
Semi thesaurus term： *アミノ酸メタボロミクス ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A0368639&from=J-GLOBAL&jstjournalNo=U1402A") }}

Author keywords (8)： amino acid metabolomics ,  pancreatic cancer cell ,  glucose depletion ,  biomarker candidate ,  amino acid metabolomics ,  pancreatic cancer cell ,  glucose depletion ,  biomarker candidate

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Pyrvinium pamoate ,  Gemcitabine hydrochloride

Reference (41)：

• 1) Vinayavekhin N, Homan EA, Saghatelian A. Exploring disease through metabolomics. ACS Chem. Biol., 5, 91-103 (2010).
• 2) Ulaszewska MM, Trost K, Stanstrup J, Tuohy KM, Franceschi P, Chong M-F-F, George T, Minihane AM, Lovegrove JA, Mattivi F. Urinary metabolomic profiling to identify biomarkers of a flavonoid-rich and flavonoid-poor fruits and vegetables diet in adults: the FLAVURS trial. Metabolomics, 12, 32 (2016).
• 3) Nishiumi S, Kobayashi T, Ikeda A, Yoshie T, Kibi M, Izumi Y, Okuno T, Hayashi N, Kawano S, Takenawa T, Azuma T, Yoshida M. A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLOS ONE, 7, e40459 (2012).
• 4) Yuliana ND, Khatib A, Verpoorte R, Choi YH. Comprehensive extraction method integrated with NMR metabolomics: a new bioactivity screening method for plants, adenosine A1 receptor binding compounds in Orthosiphon stamineus Benth. Anal. Chem., 83, 6902-6906 (2011).
• 5) Song Q, Chen H, Li Y, Zhou H, Han Q, Diao X. Toxicological effects of benzo(α)pyrene, DDT and their mixture on the green mussel Perna viridis revealed by proteomic and metabolomics approaches. Chemosphere, 144, 214-224 (2016).

Terms in the title (7)： アミノ酸 ,  メタボロミクス ,  グルコース ,  枯渇 ,  膵癌細胞 ,  抗癌薬 ,  評価