Art

J-GLOBAL ID：201802221885421785   Reference number：18A1980768

1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice

1O,20O-ジアセチルカメバカウリンはマウスにおいてアセトアミノフェン誘発型の肝毒性に対して保護する

Author (14)： YOSHIOKA Hiroki (College of Pharmacy, Kinjo Gakuin University) ,  NONOGAKI Tsunemasa (College of Pharmacy, Kinjo Gakuin University) ,  OHNISHI Hiroyuki (Department of Health Science, School of Allied Health Science and Graduate School of Medical Sciences, Kitasato University) ,  FUKUISHI Nobuyuki (College of Pharmacy, Kinjo Gakuin University) ,  YOSHIKAWA Masae (College of Pharmacy, Kinjo Gakuin University) ,  GUI Ming-Yu (Department of Chemistry, JiLin University) ,  JIN Yong-Ri (Department of Chemistry, JiLin University) ,  LI Xu-Wen (Department of Chemistry, JiLin University) ,  ADACHI Yoshiyuki (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences) ,  OHNO Naohito (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences) ,  TAKEYA Koichi (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences) ,  HITOTSUYANAGI Yukio (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences) ,  MIURA Nobuhiko (Division of Health Effects Research, Japan National Institute of Occupational Safety and Health) ,  AOYAGI Yutaka (College of Pharmacy, Kinjo Gakuin University)
Material： Biomedical Research (Web)
Volume： 39  Issue： 5  Page： 251-260(J-STAGE)  Publication year： 2018 
JST Material Number： U1102A  ISSN： 1880-313X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tetracyclic diterpene ,...
Semi thesaurus term： *Diterpenes, Kaurane ,...

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JST classification (1)： Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (3)： (1R,2R,4R,8S,9R,10S,13S,16R)-2,16-ジヒドロキシ-8-アセトキシ-9-(アセトキシメチル)-5,5-ジメチル-14-メチリデンテトラシクロ[11.2.1.01,10.04,9]ヘキサデカン-15-オン ,  Acetaminophen ,  Kamebakaurin

Reference (25)：

• 1 Aoyagi Y, Ozawa K, Kobayashi T, Hasuda T, Gui M-Y, Jin Y-R, Li X-W, Fukaya H, Yano R, Hitotsuyanagi Y and Takeya K (2014) Efficient transformation of 7,14-dihydroxy- ent-kaurenes to novel ent-abietanes having cis-fused α-methylene γ-lactones under Mitsunobu reaction conditions and their cytotoxicities. Tetrahedron 70, 3030-3041.
• 2 Christofferson DE and Yuan J (2010) Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 22, 263-268.
• 3 Ding Y, Li Q, Xu Y, Chen Y, Deng Y, Zhi F and Qian K (2016) Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice. PLoS One 11, e0154375.
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• 5 Fukaya S, Nagatsu A and Yoshioka H (2018) The Kampo formula “Juzen-taiho-to” exerts protective effects on ethanol-induced liver injury in mice. Fundam Toxicol Sci 5, 105-112.

Terms in the title (4)： マウス ,  アセトアミノフェン ,  誘発 ,  肝毒性