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J-GLOBAL ID：201802229384940503   Reference number：18A0127835

In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran

ラクトシル化デンドリマ/シクロデキストリン複合体,siRNAと低分子量sacranの三元錯体生成を利用した肝細胞へのin vitroおよびin vivoでのsiRNA送達【Powered by NICT】

Author (9)： Hayashi Yuya (Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Hayashi Yuya (Research Fellow of Japan Society for the Promotion of Science, Japan) ,  Higashi Taishi (Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Motoyama Keiichi (Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Jono Hirofumi (Department of Pharmacy, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan) ,  Jono Hirofumi (Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan) ,  Ando Yukio (Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan) ,  Arima Hidetoshi (Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Arima Hidetoshi (Program for Leading Graduate Schools ‘Health life science: Interdisciplinary and Glocal Oriented (HIGO) Program’, Kumamoto University, Japan)
Material： International Journal of Biological Macromolecules  (Int J Biol Macromol)
Volume： 107  Issue： PA  Page： 1113-1121  Publication year： 2018 
JST Material Number： T0898A  ISSN： 0141-8130  CODEN： IJBMDR  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In this study, we newly develo...

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Thesaurus term： intravenous administration ,  endosome ,  *low molecular weight ,  *complex(compound) ,  RNA interference ,  *complex(substance) ,  serum ,  *complex formation ,  *hepatocyte ,  *siRNA
Semi thesaurus term： 細胞取込 ,  抱合体 ,  *siRNAデリバリー ,  *三元錯体 , 【Automatic Indexing@JST】

Author keywords (5)： Cyclodextrin ,  Dendrimer ,  Sacran ,  Hepatocyte ,  siRNA delivery

JST classification (2)： Gene manipulation  (EC02050B) ,  Medical materials  (GA05040H)

Terms in the title (8)： デンドリマ ,  シクロデキストリン ,  複合体 ,  siRNA ,  低分子量 ,  三元錯体 ,  肝細胞 ,  siRNA送達