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J-GLOBAL ID：201802231005859645   Reference number：18A1369678

A 13-week subchronic toxicity study of acetaminophen using an obese rat model

肥満ラットモデルを用いたアセトアミノフェンの13週間亜慢性毒性試験

Author (8)： Toyoda Takeshi (Division of Pathology, National Institute of Health Sciences) ,  Cho Young-Man (Division of Pathology, National Institute of Health Sciences) ,  Akagi Jun-ichi (Division of Pathology, National Institute of Health Sciences) ,  Mizuta Yasuko (Division of Pathology, National Institute of Health Sciences) ,  Matsushita Kohei (Division of Pathology, National Institute of Health Sciences) ,  Nishikawa Akiyoshi (Biological Safety Research Center, National Institute of Health Sciences) ,  Imaida Katsumi (Onco-Pathology, Department of Pathology and Host-Defense, Kagawa University) ,  Ogawa Kumiko (Division of Pathology, National Institute of Health Sciences)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 43  Issue： 7  Page： 423-433(J-STAGE)  Publication year： 2018 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antipyretic analgesic ,...
Semi thesaurus term： NOAEL ,...

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Author keywords (4)： Subchronic toxicity ,  Obese Zucker rat ,  Obesity ,  Acetaminophen

JST classification (2)： Basic research of general anesthetics  (GW03020L) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： Acetaminophen ,  Cholesterol

Reference (27)：

• Aleixandre de Artiñano, A. and Miguel Castro, M. (2009): Experimental rat models to study the metabolic syndrome. Br. J. Nutr., 102, 1246-1253.
• Aubert, J., Begriche, K., Delannoy, M., Morel, I., Pajaud, J., Ribault, C., Lepage, S., McGill, M.R., Lucas-Clerc, C., Turlin, B., Robin, M.A., Jaeschke, H. and Fromenty, B. (2012): Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. J. Pharmacol. Exp. Ther., 342, 676-687.
• Blouin, R.A., Dickson, P., McNamara, P.J., Cibull, M. and McClain, C. (1987): Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent. J. Pharmacol. Exp. Ther., 243, 565-570.
• Burin, G.J. and Saunders, D.R. (1999): Addressing human variability in risk assessment--the robustness of the intraspecies uncertainty factor. Regul. Toxicol. Pharmacol., 30, 209-216.
• Carmiel-Haggai, M., Cederbaum, A.I. and Nieto, N. (2003): Binge ethanol exposure increases liver injury in obese rats. Gastroenterology, 125, 1818-1833.

Terms in the title (5)： 肥満 ,  ラット ,  モデル ,  アセトアミノフェン ,  亜慢性毒性試験