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J-GLOBAL ID：201802237849017201   Reference number：18A2211290

Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice

ペリジニンによるミクログリアの亜鉛増強炎症性M1表現型の減弱はマウスにおける脳虚血後の短期空間記憶障害から保護する【JST・京大機械翻訳】

Author (12)： Ueba Yusuke (Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Aratake Takaaki (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Onodera Ken-ichi (Faculty of Agriculture and Marine Science, Kochi University, 200 Otsu, Monobe, Nankoku, Kochi, 783-8502, Japan) ,  Higashi Youichirou (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Hamada Tomoya (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Shimizu Takahiro (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Shimizu Shogo (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Yawata Toshio (Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Nakamura Rina (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Akizawa Toshifumi (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Ueba Tetsuya (Department of Neurosurgery, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan) ,  Saito Motoaki (Department of Pharmacology, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, 783-8505, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 507  Issue： 1-4  Page： 476-483  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Activated microglia exhibit tw...

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Thesaurus term： *microglia ,  interaction ,  interleukin 1 ,  lipopolysaccharide ,  reperfusion ,  *zinc ,  *cerebral ischemia ,  TNF alpha ,  *phenotype ,  anti-inflammatory action ,  inflammatory cytokine ,  *mouse(animal) ,  secretion(physiology) ,  *inflammation

Author keywords (6)： Peridinin ,  Zinc ,  Spatial memory ,  Microglia ,  M1 inflammatory phenotype ,  Anti-inflammatory effect

JST classification (2)： Nervous system diseases  (GN03000O) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Peridinin

Terms in the title (11)： ペリジニン ,  ミクログリア ,  亜鉛 ,  増強 ,  炎症 ,  表現型 ,  減弱 ,  マウス ,  脳虚血 ,  短期 ,  空間記憶障害