Art

J-GLOBAL ID：201802239464516569   Reference number：18A0308435

Renin-Angiotensin System Inhibitors Can Prevent Intravenous Lipid Infusion-Induced Myocardial Microvascular Dysfunction and Leukocyte Activation

レニン - アンギオテンシン系阻害剤は静脈内脂質注入で誘発した心筋微小血管機能障害と白血球活性化を防止できる

Author (7)： Yasu Takanori (Department of Cardiovascular Medicine & Nephrology, Dokkyo Medical University Nikko Medical Center) ,  Mutoh Akiko (Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus Graduate School of Medicine) ,  Wada Hiroshi (Department of First Integrated Medicine, Saitama Medical Center, Jichi Medical University) ,  Kobayashi Mayumi (Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus Graduate School of Medicine) ,  Kikuchi Yuji (Kikuchi Microtechnology Co., Ltd.) ,  Momomura Shinichi (Department of First Integrated Medicine, Saitama Medical Center, Jichi Medical University) ,  Ueda Shinichiro (Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus Graduate School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 82  Issue： 2  Page： 494-501(J-STAGE)  Publication year： 2018 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *vascular disease ,...
Semi thesaurus term： *myocardial microcirculation disorder ,...

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Author keywords (5)： Angiotensin ,  Echocardiography ,  Microcirculation ,  Nitric oxide ,  Oxidative stress

JST classification (2)： Medicine on cardiovascular system in general  (GJ01010Z) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (2)： Candesartan ,  Perindopril

Reference (41)：

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• 2. Pilz S, Scharnagl H, Tiran B, Wellnitz B, Seelhorst U, Boehm BO, et al. Elevated plasma free fatty acids predict sudden cardiac death: A 6.85-year follow-up of 3315 patients after coronary angiography. Eur Heart J 2007; 28: 2763-2769.
• 3. Pilz S, Scharnagl H, Tiran B, Seelhorst U, Wellnitz B, Bernhard O, et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 2006; 90: 3622-3628.
• 4. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, et al. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997; 100: 1230-1239.
• 5. Kim F, Tysseling KA, Rice J, Pham M, Haji L, Gallis BM, et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 2005; 25: 989-994.

Terms in the title (11)： レニン ,  アンギオテンシン ,  阻害剤 ,  静脈 ,  脂質 ,  注入 ,  誘発 ,  心筋 ,  微小血管 ,  機能障害 ,  白血球活性化