Art

J-GLOBAL ID：201802245495009140   Reference number：18A2219892

Investigation on drug-binding in heme pocket of CYP2C19 with UV-visible and resonance Raman spectroscopies

UV-可視および共鳴Raman分光法によるCYP2C19のヘムポケットにおける薬物結合に関する研究【JST・京大機械翻訳】

Author (7)： Derayea Sayed M. (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan) ,  Derayea Sayed M. (Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt) ,  Tsujino Hirofumi (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan) ,  Oyama Yukiko (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oehonmachi, Kumamoto 862-0973, Japan) ,  Ishikawa Yoshinobu (Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Yamashita Taku (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, 11-68 Koshien-Kyubancho, Nishinomiya 663-8179, Japan) ,  Uno Tadayuki (Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan)
Material： Spectrochimica Acta. Part A. Molecular and Biomolecular Spectroscopy  (Spectrochimica Acta. Part A. Molecular Spectroscopy)
Volume： 209  Page： 209-216  Publication year： 2019 
JST Material Number： E0128B  ISSN： 1386-1425  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cytochrome P450 (CYP) is a cla...

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Thesaurus term： water molecule ,  chemical substance ,  drug metabolism ,  *Raman spectroscopy ,  cytochrome P450 ,  catalyst ,  dissociation constant ,  interaction ,  lactone ,  polynuclear aromatic compound ,  hydroxy ketone ,  phenol ether ,  aminoalcohol ,  secondary amine ,  secondary alcohol ,  sulfide(organic) ,  nitrogen heterocyclic compound ,  cyanamide ,  ether ,  sulfoxide ,  organofluorine compound ,  aromatic compound ,  lactam ,  urea compound
Semi thesaurus term： アイソフォーム , 【Automatic Indexing@JST】

Author keywords (4)： CYP2C19 ,  Raman spectroscopy spectrophotometry ,  Drug binding ,  Substrate recognition

JST classification (1)： Cobalt bnd nickel complexes  (CE01092Y)

Substance index (6)： Warfarin ,  Propranolol ,  Cimetidine ,  Lansoprazole ,  Phenytoin ,  Omeprazole

Terms in the title (5)： 共鳴Raman分光法 ,  CYP2C19 ,  ヘム ,  薬物 ,  研究